Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1261544 | 0.86 | — | — | |
| SCHEMBL8736180 | 0.86 | TBXAS1 (0.47) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL8138463 | 0.82 | KMT2A (0.44) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL7574578 | 0.82 | NPC1 (0.46) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL10997776 | 0.82 | TBXAS1 (0.49) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL29163121 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL7472243 | 0.81 | NPC1 (0.45) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL13255601 | 0.81 | KMT2A (0.42) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL647801 | 0.81 | NPC1 (0.41) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8694313 | 0.81 | KMT2A (0.42) | NPC1RAB9AKMT2ATBXAS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874769-B1 | NOVEL AZA- HETEROCYCLES SERVING AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-09-14 | — | — | EP | claimed |
| US-20040204367-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO. (US) | 2004-10-14 | — | — | US | claimed |
| US-6613880-B2 | Autoimmune diseases; inflammatory conditions; competitive binding with Human Leukocyte Antigen displacing disease-inducing endogenous peptides | PHARMACIA CORPORATION | 2003-09-02 | — | — | US | claimed |
| EP-1155001-A4 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | LION BIOSCIENCE AG (DE) | 2003-05-28 | — | — | EP | claimed |
| EP-1210598-A4 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-10-30 | — | — | EP | claimed |
| US-6452009-B1 | A LARGE NUMBER OF RELATED ANALOGS ARE THEN SYNTHESIZED IN ORDER TO DEVELOP A STRUCTURE-ACTIVITY RELATIONSHIP | LION BIOSCIENCE AG (DE) | 2002-09-17 | — | — | US | claimed |
| US-6417195-B1 | LIBRARIES AND COMBINATORIAL CHEMISTRY | LION BIOSCIENCE AG (DE) | 2002-07-09 | — | — | US | claimed |
| EP-1210598-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2002-06-05 | — | — | EP | claimed |
| EP-1155001-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 2001-11-21 | — | — | EP | claimed |
| US-20010027247-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO., (US) | 2001-10-04 | — | — | US | claimed |
| WO-2001014879-A1 | 4-UNSUBSTITUTED DIHYDROISOQUINOLINONE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-03-01 | — | — | WO | claimed |
| WO-2000050406-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | LION BIOSCIENCE AG (DE) | 2000-08-31 | — | — | WO | claimed |
| EP-3091019-B1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2019-04-03 | — | — | EP | disclosed |
| US-10172863-B2 | Purine derivatives useful as HSP90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2019-01-08 | — | — | US | disclosed |
| US-9956520-B2 | Liquid carbon dioxide absorbents, methods of using the same, and related systems | GENERAL ELECTRIC COMPANY (US) | 2018-05-01 | — | — | US | disclosed |
| US-20160375400-A1 | LIQUID CARBON DIOXIDE ABSORBENTS, METHODS OF USING THE SAME, AND RELATED SYSTEMS | AIR PRODUCTS AND CHEMICALS, INC. | 2016-12-29 | — | — | US | disclosed |
| WO-1996040753-A1 | PIPECOLIC ACID DERIVATIVES OF PROLINE THREONINE AMIDES USEFUL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0722436-A4 | MERCAPTOSULFIDE METALLOPROTEINASE INHIBITORS | UNIV FLORIDA STATE (US) | 1996-11-20 | — | — | EP | disclosed |
| EP-0722436-A1 | MERCAPTOSULFIDE METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1996-07-24 | — | — | EP | disclosed |
| WO-1995009833-A1 | MERCAPTOSULFIDE METALLOPROTEINASE INHIBITORS | FLORIDA STATE UNIVERSITY (US) | 1995-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010027247-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | ARGLU1, PRR12, PTMS | NPC1 4785/4885RAB9A 3045/4885KMT2A 2129/4885 |
| US-10172863-B2 | Purine derivatives useful as HSP90 inhibitors | XDH, HSP90B1, HSP90AA1 | NPC1 2300/4885RAB9A 2768/4885KMT2A 4154/4885 |
| US-20040204367-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | ARGLU1, PRR12, PTMS | NPC1 4785/4885RAB9A 3045/4885KMT2A 2129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.