SCHEMBL12377314

SCHEMBL12377314

CC(C)n1c(NCc2cccc(Oc3ccccc3)c2)nc2cc(C(F)(F)F)cc(Cl)c21

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
FFAR1 O14842 6/20 0.40
POLB P06746 1/20 0.39
MAPK14 Q16539 1/20 0.38
P2RX7 Q99572 2/20 0.37
PPARG P37231 1/20 0.37
PPARD Q03181 1/20 0.37
PPARA Q07869 1/20 0.37
MITF O75030 1/20 0.36
MET P08581 1/20 0.36
APP P05067 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12412631 0.90 ALOX15 (0.42) MEN1KMT2AFFAR1POLBMAPK14
SCHEMBL12377291 0.89 MET (0.43) MEN1KMT2AP2RX7METAPP
SCHEMBL12377284 0.85 MAPT (0.40) MEN1KMT2AP2RX7METALDH1A1
SCHEMBL12377300 0.84 MRGPRX1 (0.46) MEN1KMT2AFFAR1MAPK14MITF
SCHEMBL12377283 0.84 MAPT (0.42) MEN1KMT2AP2RX7METAPP
SCHEMBL12377322 0.81 KMT2A (0.44) MEN1KMT2AHTTSMN1; SMN2
SCHEMBL12377280 0.79 GAA (0.39) KMT2APOLBP2RX7SMN1; SMN2
SCHEMBL12413900 0.78 NPC1 (0.49) MEN1KMT2AP2RX7METALDH1A1
SCHEMBL12412021 0.74 NPC1 (0.46) KMT2APOLBP2RX7METALDH1A1
SCHEMBL12377297 0.72 HSD17B10 (0.43) METSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7989422-B2 Antibacterial agents ALCHEMIA LIMITED (AU) 2011-08-02 US disclosed
US-20090023669-A1 Antibacterial Agents ALCHEMIA LIMITED (AU) 2009-01-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023669-A1 Antibacterial Agents MRPL21, FUT6, FUT5 MEN1 2906/4885KMT2A 4563/4885FFAR1 1877/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.