SCHEMBL12377643

SCHEMBL12377643

Fc1cc(F)c(-c2ccccn2)cc1-c1ccccn1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.54
LMNA P02545 3/20 0.54
CCR1 P32246 3/20 0.54
CCR5 P51681 3/20 0.54
CCR8 P51685 3/20 0.54
CYP1A2 P05177 1/20 0.54
POLB P06746 1/20 0.54
METAP1 P53582 1/20 0.54
BLM P54132 1/20 0.54
HIF1A Q16665 1/20 0.54
DOHH Q9BU89 1/20 0.54
P4HTM Q9NXG6 1/20 0.54
RAB9A P51151 5/20 0.46
NPC1 O15118 5/20 0.46
TP53 P04637 3/20 0.46
TDP1 Q9NUW8 2/20 0.46
ALOX15 P16050 2/20 0.46
HTT P42858 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31400260 1.00 KDM4E (0.54) KDM4ELMNACCR1CCR5CCR8
Hydrochloric Acid SCHEMBL27906275 0.98 KDM4E (0.52) KDM4ELMNACCR1CCR5CCR8
SCHEMBL5844795 0.94 KDM4E (0.52) KDM4ELMNACCR1CCR5CCR8
SCHEMBL21215463 0.87 KDM4E (0.45) KDM4ELMNACCR1CCR5CCR8
SCHEMBL30117406 0.87 CCR1 (0.46) KDM4ELMNACCR1CCR5CCR8
SCHEMBL21215438 0.87 KDM4E (0.45) KDM4ELMNACCR1CCR5CCR8
SCHEMBL7496516 0.86 KDM4E (0.48) KDM4ELMNACCR1CCR5CCR8
SCHEMBL29914871 0.84 TGFBR1 (0.47) KDM4ELMNACCR1CCR5CCR8
SCHEMBL4578342 0.84 GRM4 (0.43) KDM4ELMNACCR1CCR5CCR8
SCHEMBL29725567 0.84 KDM4E (0.68) KDM4ELMNACCR1CCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12116378-B2 Transition metal luminescent complexes and methods of use THE UNIVERSITY OF HONG KONG (CN) 2024-10-15 US disclosed
CN-109232660-B Iridium complex with double-tridentate structure as well as preparation method and application thereof 南京工业大学 2020-07-17 CN disclosed
US-20200176691-A1 TRANSITION METAL LUMINESCENT COMPLEXES AND METHODS OF USE UNIV HONG KONG (HK) 2020-06-04 US disclosed
US-20200172562-A1 TRANSITION METAL LUMINESCENT COMPLEXES AND METHODS OF USE THE UNIVERSITY OF HONG KONG (HK) 2020-06-04 US disclosed
US-9219237-B1 Heteroleptic Ir(III) phosphors with bis-tridentate chelating architecture for high efficiency OLEDs NATIONAL TSING HUA UNIVERSITY (TW) 2015-12-22 US disclosed
US-9219237-B1 Heteroleptic Ir(III) phosphors with bis-tridentate chelating architecture for high efficiency OLEDs NATIONAL TSING HUA UNIVERSITY (TW) 2015-12-22 US disclosed
US-9219237-B1 Heteroleptic Ir(III) phosphors with bis-tridentate chelating architecture for high efficiency OLEDs NATIONAL TSING HUA UNIVERSITY (TW) 2015-12-22 US disclosed
US-7999103-B2 Metal complex compound and organic electroluminescence device using the compound CHUO UNIVERSITY (JP) 2011-08-16 US disclosed
US-7999103-B2 Metal complex compound and organic electroluminescence device using the compound CHUO UNIVERSITY (JP) 2011-08-16 US disclosed
US-20090102363-A1 METAL COMPLEX COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2009-04-23 US disclosed
US-20090039767-A1 METAL COMPLEX COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2009-02-12 US disclosed
US-7459559-B2 Metal complex and organic light-emitting device CANON KABUSHIKI KAISHA (JP) 2008-12-02 US disclosed
US-7459559-B2 Metal complex and organic light-emitting device CANON KABUSHIKI KAISHA (JP) 2008-12-02 US disclosed
EP-1961743-A1 METAL COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME Chuo University (JP) 2008-08-27 EP disclosed
US-20080079358-A1 Organic electroluminescent element FUJIFILM CORPORATION 2008-04-03 US disclosed
US-20080079358-A1 Organic electroluminescent element FUJIFILM CORPORATION 2008-04-03 US disclosed
US-20070278939-A1 METAL COMPLEX AND ORGANIC LIGHT-EMITTING DEVICE CANON KABUSHIKI KAISHA (JP) 2007-12-06 US disclosed
US-20070278939-A1 METAL COMPLEX AND ORGANIC LIGHT-EMITTING DEVICE CANON KABUSHIKI KAISHA (JP) 2007-12-06 US disclosed
US-20070138437-A1 METAL COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE COMPOUND CHUO UNIVERSITY (JP) 2007-06-21 US disclosed
US-20070138437-A1 METAL COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE COMPOUND CHUO UNIVERSITY (JP) 2007-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12116378-B2 Transition metal luminescent complexes and methods of use OCIAD2, OCIAD1, OPRD1 KDM4E 4696/4885LMNA 2898/4885CCR1 3876/4885
US-20200176691-A1 TRANSITION METAL LUMINESCENT COMPLEXES AND METHODS OF USE OCIAD2, OCIAD1, OPRD1 KDM4E 4696/4885LMNA 2898/4885CCR1 3876/4885
US-20090102363-A1 METAL COMPLEX COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME EPCAM, L1CAM, EMC2 KDM4E 469/4885LMNA 1800/4885CCR1 2426/4885
US-20090039767-A1 METAL COMPLEX COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME EPCAM, EMC2, L1CAM KDM4E 524/4885LMNA 1772/4885CCR1 2382/4885
US-20070278939-A1 METAL COMPLEX AND ORGANIC LIGHT-EMITTING DEVICE CLTC, CLTA, CLTB KDM4E 2872/4885LMNA 4091/4885CCR1 3323/4885
US-20200172562-A1 TRANSITION METAL LUMINESCENT COMPLEXES AND METHODS OF USE OCIAD2, OCIAD1, OPRD1 KDM4E 4696/4885LMNA 2898/4885CCR1 3876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.