Sugi Predict

Sugi Predict / Compounds / SCHEMBL12384

SCHEMBL12384

SCHEMBL12384

CC(C)CN1CCC[C@@H](C)C1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.61
▸ MEN1 O00255 2/20 0.46
▸ KMT2A Q03164 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ MAPK1 P28482 1/20 0.44
▸ PIK3CD O00329 2/20 0.44
▸ HSD17B10 Q99714 1/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ CYP3A4 P08684 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ LMNA P02545 2/20 0.40
▸ POLB P06746 1/20 0.39
▸ CASP2 P42575 1/20 0.39
▸ RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12000484 1.00 KDM4E (0.61) KDM4EMEN1KMT2AALDH1A1MAPK1
SCHEMBL12449688 1.00 KDM4E (0.61) KDM4EMEN1KMT2AALDH1A1MAPK1
SCHEMBL21864494 0.96 KDM4E (0.56) KDM4EMEN1KMT2AALDH1A1MAPK1
SCHEMBL12448180 0.87 PIK3CD (0.47) KDM4EMEN1KMT2AALDH1A1PIK3CD
SCHEMBL10130181 0.87 PIK3CD (0.47) KDM4EMEN1KMT2AALDH1A1PIK3CD
SCHEMBL10130209 0.87 PIK3CD (0.47) KDM4EMEN1KMT2AALDH1A1PIK3CD
SCHEMBL12718136 0.82 KDM4E (0.59) KDM4EMEN1KMT2AALDH1A1MAPK1
SCHEMBL13077 0.82 KDM4E (0.50) KDM4EALDH1A1LMNA
SCHEMBL22212203 0.82 ACHE (0.47) KDM4EMEN1KMT2APIK3CDLMNA
SCHEMBL12449634 0.82 KDM4E (0.50) KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024081311-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2024-04-18 — — WO disclosed
US-11834447-B2 Indole derivatives and use thereof PURDUE PHARMA L.P. (US) 2023-12-05 — — US disclosed
CN-117062811-A 3- (1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and medical use thereof 诺华股份有限公司 2023-11-14 — — CN disclosed
EP-3448838-B1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF BIOSPLICE THERAPEUTICS INC (US) 2021-08-11 — — EP disclosed
US-10005768-B2 Carboxamide derivatives and use thereof PURDUE PHARMA L.P. (US) 2018-06-26 — — US disclosed
US-20180134690-A1 INDAZOLES AND USE THEREOF PURDUE PHARMA LP (US) 2018-05-17 — — US disclosed
US-9834543-B2 Indazoles and use thereof PURDUE PHARMA L.P. (US) 2017-12-05 — — US disclosed
US-20170283392-A1 DIBENZAZEPINE DERIVATIVES AND USE THEREOF PURDUE PHARMA L.P. 2017-10-05 — — US disclosed
US-9745287-B2 Pyrimidines and use thereof PURDUE PHARMA L.P. (US) 2017-08-29 — — US disclosed
US-9695144-B2 Dibenzazepine derivatives and use thereof PURDUE PHARMA L.P. (US) 2017-07-04 — — US disclosed
US-9493449-B2 Carboxamide derivatives and use thereof PURDUE PHARMA L.P. (US) 2016-11-15 — — US disclosed
EP-2499146-B1 TRICYCLIC PYRAZOL AMINE DERIVATIVES MERCK SERONO SA (CH) 2016-09-21 — — EP disclosed
US-20160031873-A1 Carboxamide Derivatives and Use Thereof PURDUE PHARMA L.P. 2016-02-04 — — US disclosed
US-20150284383-A1 INDOLE DERIVATIVES AND USE THEREOF PURDUE PHARMA L.P. 2015-10-08 — — US disclosed
US-9073940-B2 Tricyclic pyrazol amine derivatives MERCK SERONO SA (CH) 2015-07-07 — — US disclosed
US-9073940-B2 Tricyclic pyrazol amine derivatives MERCK SERONO SA (CH) 2015-07-07 — — US disclosed
US-20150175569-A1 DIBENZAZEPINE DERIVATIVES AND USE THEREOF PURDUE PHARMA L.P. 2015-06-25 — — US disclosed
US-20120238545-A1 TRICYCLIC PYRAZOL AMINE DERIVATIVES MERCK SERONO SA (CH) 2012-09-20 — — US disclosed
US-20120238545-A1 TRICYCLIC PYRAZOL AMINE DERIVATIVES MERCK SERONO SA (CH) 2012-09-20 — — US disclosed
WO-2011058149-A1 TRICYCLIC PYRAZOL AMINE DERIVATIVES MERCK SERONO S.A. (CH) 2011-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120238545-A1 TRICYCLIC PYRAZOL AMINE DERIVATIVES PI4KB, MTOR, PI4KA KDM4E 1093/4885MEN1 1024/4885KMT2A 936/4885
US-11834447-B2 Indole derivatives and use thereof TRPC4, TRPV4, TRPV1 KDM4E 206/4885MEN1 1788/4885KMT2A 1731/4885
US-20170283392-A1 DIBENZAZEPINE DERIVATIVES AND USE THEREOF CACNA1A, CACNA1D, CACNA1S KDM4E 1692/4885MEN1 1265/4885KMT2A 584/4885
US-20150175569-A1 DIBENZAZEPINE DERIVATIVES AND USE THEREOF CACNA1A, CACNA1D, CACNA1S KDM4E 1692/4885MEN1 1265/4885KMT2A 584/4885
US-10005768-B2 Carboxamide derivatives and use thereof TRPV1, CACNA1A, SCN10A KDM4E 1185/4885MEN1 3470/4885KMT2A 1142/4885
US-20160031873-A1 Carboxamide Derivatives and Use Thereof TRPV1, CACNA1A, SCN10A KDM4E 776/4885MEN1 3687/4885KMT2A 956/4885
US-20150284383-A1 INDOLE DERIVATIVES AND USE THEREOF TRPC4, TRPV4, TRPV1 KDM4E 206/4885MEN1 1788/4885KMT2A 1731/4885
US-20180134690-A1 INDAZOLES AND USE THEREOF TRPV3, TRPA1, TRPV1 KDM4E 1749/4885MEN1 2800/4885KMT2A 2502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.