Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13236680 | 1.00 | BUB1 (0.32) | BUB1 | |
| SCHEMBL9281239 | 0.89 | BUB1 (0.34) | BUB1 | |
| SCHEMBL3179253 | 0.89 | BUB1 (0.34) | BUB1 | |
| SCHEMBL8536413 | 0.89 | BUB1 (0.34) | BUB1 | |
| SCHEMBL1799927 | 0.85 | BUB1 (0.36) | BUB1 | |
| SCHEMBL4606908 | 0.81 | PPM1D (0.33) | BUB1 | |
| SCHEMBL4606548 | 0.81 | PPM1D (0.33) | BUB1 | |
| SCHEMBL18378218 | 0.81 | BUB1 (0.32) | BUB1 | |
| SCHEMBL4645059 | 0.81 | PPM1D (0.33) | BUB1 | |
| SCHEMBL11313059 | 0.79 | BUB1 (0.31) | BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180117156-A1 | 1-DEOXY ANALOGS OF VITAMIN D-RELATED COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-05-03 | — | — | US | disclosed |
| US-9775903-B2 | 1-deoxy analogs of 1,25-dihydroxyvitamin D3 compounds | JOHNS HOPKINS UNIVERSITY (US) | 2017-10-03 | — | — | US | disclosed |
| US-9212136-B2 | Methods for producing paricalcitol | AZAD PHARMACEUTICALS INGREDIENTS AG (CH) | 2015-12-15 | — | — | US | disclosed |
| US-20130157987-A1 | 1-DEOXY ANALOGS OF 1,25-DIHYDROXYVITAMIN D3 COMPOUNDS | JOHNS HOPKINS UNIVERSITY (US) | 2013-06-20 | — | — | US | disclosed |
| US-20110184199-A1 | Methods For Producing Paricalcitol | AZAD PHARMA AG (CH) | 2011-07-28 | — | — | US | disclosed |
| US-20100016435-A1 | HYBRID MOLECULES HAVING MIXED VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITORY PROPERTIES | MCGILL UNIVERSITY (CA) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130157987-A1 | 1-DEOXY ANALOGS OF 1,25-DIHYDROXYVITAMIN D3 COMPOUNDS | CYP24A1, CYP2R1, CYP27B1 | BUB1 2863/4885 |
| US-20100016435-A1 | HYBRID MOLECULES HAVING MIXED VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITORY PROPERTIES | VDR, HDAC3, HDAC4 | BUB1 4176/4885 |
| US-20180117156-A1 | 1-DEOXY ANALOGS OF VITAMIN D-RELATED COMPOUNDS | CYP24A1, CYP2R1, VDR | BUB1 2969/4885 |
| US-20110184199-A1 | Methods For Producing Paricalcitol | CYP2R1, PTH1R, CYP24A1 | BUB1 2891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.