Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | SPR | P35270 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16328220 | 0.89 | HTR1A (0.53) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL12401699 | 0.89 | MTNR1A (0.58) | MTNR1AMTNR1BNOTUMCYP1A2SPR | |
| SCHEMBL12404686 | 0.86 | MTNR1A (0.63) | HTR1AMTNR1AMTNR1BNOTUMCYP1A2 | |
| SCHEMBL12404682 | 0.84 | HTR1A (0.44) | HTR1AHTR1DHTR1BCYP1A2KDM4E | |
| SCHEMBL12401667 | 0.83 | MTNR1A (0.47) | MTNR1AMTNR1BMAPTKMT2APOLB | |
| SCHEMBL15338726 | 0.77 | SPR (0.62) | NOTUMCYP1A2SPRKDM4EALDH1A1 | |
| SCHEMBL19229515 | 0.77 | MTNR1A (0.74) | HTR1AHTR1DHTR1BMTNR1AMTNR1B | |
| SCHEMBL14943234 | 0.75 | MTNR1A (0.66) | HTR1AMTNR1AMTNR1BNOTUMCYP1A2 | |
| SCHEMBL12468420 | 0.74 | MTNR1A (0.65) | HTR1AMTNR1AMTNR1BNOTUMCYP1A2 | |
| SCHEMBL14943212 | 0.73 | HTR1A (0.47) | HTR1AHTR1DHTR1BCYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372873-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, SPINT2, PRSS2 | HTR1A 2480/4885HTR1D 2934/4885HTR1B 2819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.