Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | RRM1 | P23921 | 2/20 | 0.33 |
| ▸ | RRM2 | P31350 | 2/20 | 0.33 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24568578 | 0.83 | CNR2 (0.37) | CNR2NPSR1ASAH1TSHRCYP2C9 | |
| SCHEMBL26412098 | 0.83 | CNR2 (0.37) | CNR2NPSR1ASAH1TSHRCYP2C9 | |
| SCHEMBL25587258 | 0.83 | CNR2 (0.37) | CNR2NPSR1ASAH1TSHRCYP2C9 | |
| SCHEMBL24380351 | 0.83 | EPHX1 (0.41) | TSHRRRM1RRM2RRM2BPRSS1 | |
| SCHEMBL25587257 | 0.83 | CNR2 (0.37) | CNR2NPSR1ASAH1TSHRCYP2C9 | |
| SCHEMBL12741095 | 0.82 | ASAH1 (0.37) | CNR2NPSR1ASAH1TSHRCYP2C9 | |
| SCHEMBL21789730 | 0.82 | ASAH1 (0.37) | CNR2NPSR1ASAH1TSHRCYP2C9 | |
| SCHEMBL23612990 | 0.82 | ASAH1 (0.37) | CNR2NPSR1ASAH1TSHRCYP2C9 | |
| SCHEMBL12086289 | 0.79 | KDM4E (0.35) | NPSR1TSHRRRM1RRM2RRM2B | |
| SCHEMBL14376297 | 0.79 | KDM4E (0.35) | NPSR1TSHRRRM1RRM2RRM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575208-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-11-05 | — | — | US | disclosed |
| US-7985762-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |
| US-20100272681-A1 | Inhibitors of Serine Proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-10-28 | — | — | US | disclosed |
| US-20070179167-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179167-A1 | Inhibitors of serine proteases | PRSS1, PRSS3, PRSS2 | CNR2 4832/4885NPSR1 1382/4885ASAH1 979/4885 |
| US-20100272681-A1 | Inhibitors of Serine Proteases | SERPINB1, PRSS1, SPINT2 | CNR2 4186/4885NPSR1 2299/4885ASAH1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.