Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24568578 | 1.00 | CNR2 (0.37) | CNR2ASAH1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL25587257 | 1.00 | CNR2 (0.37) | CNR2ASAH1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL25590074 | 0.83 | ASAH1 (0.36) | CNR2ASAH1NPSR1L3MBTL1POLB | |
| SCHEMBL25590071 | 0.83 | ASAH1 (0.36) | CNR2ASAH1NPSR1L3MBTL1POLB | |
| SCHEMBL25590075 | 0.83 | ASAH1 (0.36) | CNR2ASAH1NPSR1L3MBTL1POLB | |
| SCHEMBL12404657 | 0.83 | CNR2 (0.39) | CNR2ASAH1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL17777049 | 0.78 | CTRB1 (0.39) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL22286768 | 0.78 | ALDH1A1 (0.34) | CYP2D6CYP2C19PRSS1CTSGCTRB1 | |
| SCHEMBL17777038 | 0.78 | CTRB1 (0.39) | TSHRPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL30675671 | 0.75 | GAA (0.39) | PRSS1CTSGCTRB1CMA1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-09-07 | — | — | US | disclosed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278958-A1 | TRICYCLIC HETEROCYCLES | YAP1, TERF2IP, TEAD1 | CNR2 4431/4885ASAH1 3833/4885NPSR1 4691/4885 |
| US-20230174538-A1 | Tricyclic heterocycles | YAP1, TEAD1, TERF2IP | CNR2 4236/4885ASAH1 3953/4885NPSR1 4695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.