Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18418867 | 0.81 | MAPT (0.37) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 | |
| SCHEMBL21291535 | 0.77 | CHEK1 (0.39) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 | |
| SCHEMBL18418866 | 0.75 | CHEK1 (0.40) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 | |
| SCHEMBL12025942 | 0.75 | CHEK1 (0.43) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 | |
| SCHEMBL610407 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL12494921 | 0.70 | PKM (0.37) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 | |
| SCHEMBL15814352 | 0.69 | L3MBTL1 (0.37) | CHEK1DAPK3GRK5LIMK1MAPT | |
| SCHEMBL15813569 | 0.69 | VCAM1 (0.37) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 | |
| SCHEMBL15834231 | 0.69 | CHEK1 (0.36) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 | |
| SCHEMBL15764571 | 0.69 | MAPT (0.48) | CHEK1DAPK3GRK5LIMK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166124-A1 | TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE | MCCORMICK KEVIN D | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166124-A1 | TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE | GPR119, TRPV1, NR3C2 | CHEK1 1842/4885DAPK3 2559/4885GRK5 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.