Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAN2A1 | Q16706 | 1/20 | 0.54 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | CASR | P41180 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3681375 | 0.91 | GAA (0.61) | SIGMAR1GAAL3MBTL1MAN2A1MAN1B1 | |
| SCHEMBL3681373 | 0.91 | GAA (0.61) | SIGMAR1GAAL3MBTL1MAN2A1MAN1B1 | |
| SCHEMBL28260287 | 0.82 | MTOR (0.56) | SIGMAR1GAAL3MBTL1CYP3A4SLC6A4 | |
| SCHEMBL8794354 | 0.81 | SIGMAR1 (0.45) | SIGMAR1GAAL3MBTL1MAN2A1MAN1B1 | |
| SCHEMBL3044650 | 0.81 | SIGMAR1 (0.45) | SIGMAR1GAAL3MBTL1MAN2A1MAN1B1 | |
| SCHEMBL8222529 | 0.79 | POLB (0.44) | SIGMAR1GAAL3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL28555177 | 0.78 | ANPEP (0.47) | SIGMAR1ALDH1A1APAF1POLBANPEP | |
| Hydrochloric Acid SCHEMBL7624461 | 0.77 | SIGMAR1 (0.49) | SIGMAR1GAAL3MBTL1CYP3A4CYP2D6 | |
| SCHEMBL27099588 | 0.77 | HTR2C (0.49) | SIGMAR1GAAL3MBTL1MAN2A1MAN1B1 | |
| SCHEMBL24406703 | 0.76 | CYP3A4 (0.76) | SIGMAR1CYP3A4CHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372847-B2 | Pyrazinone modulator of corticotropin-releasing factor receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110166160-A1 | Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity | BRISTOL-MYERS SQUIBB COMPANY | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166160-A1 | Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity | CRH, CRHR1, CRHR2 | SIGMAR1 202/4885GAA 4565/4885L3MBTL1 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.