Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MAN2A1 | Q16706 | 1/20 | 0.38 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28138387 | 0.91 | HTT (0.43) | SIGMAR1MAN2A1MAN1B1GAAL3MBTL1 | |
| SCHEMBL12410231 | 0.81 | SIGMAR1 (0.61) | SIGMAR1MAN2A1MAN1B1GAAL3MBTL1 | |
| SCHEMBL8794354 | 0.78 | SIGMAR1 (0.45) | SIGMAR1MAN2A1MAN1B1GAAL3MBTL1 | |
| SCHEMBL3927019 | 0.76 | SLC6A4 (0.38) | SIGMAR1CYP3A4CHRM2HTR1AADRA2A | |
| SCHEMBL3042629 | 0.73 | LMNA (0.44) | SIGMAR1GAAPARP1CYP3A4CHRM2 | |
| SCHEMBL3681373 | 0.73 | GAA (0.61) | SIGMAR1MAN2A1MAN1B1GAAL3MBTL1 | |
| SCHEMBL3681375 | 0.73 | GAA (0.61) | SIGMAR1MAN2A1MAN1B1GAAL3MBTL1 | |
| SCHEMBL3041726 | 0.72 | CYP3A4 (0.43) | CYP3A4CHRM2HTR1AADRA2AADORA3 | |
| SCHEMBL10528067 | 0.71 | GAA (0.46) | SIGMAR1MAN2A1MAN1B1GAAL3MBTL1 | |
| SCHEMBL12982580 | 0.70 | RIPK1 (0.35) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA (SE) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | BRAF, RAF1, ARAF | SIGMAR1 4723/4885MAN2A1 2159/4885MAN1B1 3993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.