Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12410458 | 0.84 | NPC1 (0.40) | PKMNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL14863999 | 0.78 | PKM (0.50) | PKMNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL12412446 | 0.77 | PKM (0.49) | PKMNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL13049166 | 0.74 | PKM (0.51) | PKMNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL12410462 | 0.71 | CYP4F2 (0.41) | NPC1RAB9ASMN1; SMN2CA1CA2 | |
| SCHEMBL12410588 | 0.71 | GAA (0.42) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL22811121 | 0.71 | PKM (0.73) | PKMNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL17426918 | 0.69 | LMNA (0.45) | PKMRAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL13397224 | 0.67 | ALDH1A1 (0.51) | PKMNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL12143611 | 0.66 | LMNA (0.45) | PKMRAB9ASMN1; SMN2KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8449872-B2 | Polymer conjugates of nesiritide peptides | NEKTAR THERAPEUTICS (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110165111-A1 | POLYMER CONJUGATES OF NESIRITIDE PEPTIDES | NEKTAR THERAPEUTICS (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165111-A1 | POLYMER CONJUGATES OF NESIRITIDE PEPTIDES | NGLY1, IAPP, NPSR1 | PKM 4156/4885NPC1 759/4885RAB9A 3064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.