Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR6 | P50406 | 4/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391217 | 0.90 | DRD2 (0.56) | MEN1KMT2ADRD2DRD3HTR1A | |
| SCHEMBL17844904 | 0.90 | DRD2 (0.56) | MEN1KMT2ADRD2DRD3HTR1A | |
| SCHEMBL29944565 | 0.88 | ALDH1A1 (0.57) | MEN1KMT2ADRD2DRD3HTR1A | |
| SCHEMBL829637 | 0.88 | ALDH1A1 (0.57) | MEN1KMT2ADRD2DRD3HTR1A | |
| SCHEMBL29263692 | 0.86 | MAOB (0.57) | MEN1KMT2ADRD2DRD3HTR1A | |
| SCHEMBL12263981 | 0.86 | MAOB (0.57) | MEN1KMT2ADRD2DRD3HTR1A | |
| SCHEMBL5307175 | 0.85 | DRD2 (0.52) | MEN1KMT2ADRD2DRD3HTR1A | |
| SCHEMBL12501840 | 0.84 | MEN1 (0.55) | MEN1KMT2APOLBRXFP1DRD2 | |
| SCHEMBL29659287 | 0.83 | KMT2A (0.57) | MEN1KMT2APOLBRXFP1DRD2 | |
| SCHEMBL578012 | 0.83 | KMT2A (0.57) | MEN1KMT2APOLBRXFP1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288387-B2 | Napthalimide-benzimidazole hybrids as potential antitumor agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-10-16 | — | — | US | disclosed |
| US-20110166346-A1 | NOVEL NAPTHALIMIDE-BENZIMIDAZOLE HYBRIDS AS POTENTIAL ANTITUMOR AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166346-A1 | NOVEL NAPTHALIMIDE-BENZIMIDAZOLE HYBRIDS AS POTENTIAL ANTITUMOR AGENTS AND PROCESS FOR THE PREPARATION THEREOF | NAP1L4, NAP1L1, CCNI | MEN1 467/4885KMT2A 682/4885POLB 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.