Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 7/20 | 0.34 |
| ▸ | MMP8 | P22894 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 6/20 | 0.31 |
| ▸ | MMP9 | P14780 | 6/20 | 0.31 |
| ▸ | MMP2 | P08253 | 6/20 | 0.31 |
| ▸ | MMP13 | P45452 | 3/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12401065 | 0.83 | ALDH1A1 (0.32) | — | |
| SCHEMBL12401352 | 0.83 | MAPT (0.46) | MAPTCYP2D6CYP2C19EPHX1MMP1 | |
| SCHEMBL14943560 | 0.81 | MAPT (0.47) | MAPTCYP2D6CYP2C19EPHX1MMP1 | |
| SCHEMBL8242026 | 0.79 | MAPT (0.46) | MAPTCYP2D6CYP2C19EPHX1MMP1 | |
| SCHEMBL15219597 | 0.79 | MAPT (0.46) | MAPTCYP2D6CYP2C19EPHX1MMP1 | |
| SCHEMBL12467406 | 0.78 | MAPT (0.45) | MAPTCYP2D6CYP2C19EPHX1MMP1 | |
| SCHEMBL12571864 | 0.75 | TRPA1 (0.36) | MAPTPOLBKMT2A | |
| SCHEMBL12571865 | 0.73 | EPHX1 (0.45) | CYP2D6EPHX1MMP1MMP8MMP3 | |
| SCHEMBL12413598 | 0.70 | ALDH1A1 (0.41) | EPHX1KDM4ELMNA | |
| SCHEMBL777387 | 0.69 | MAPT (0.59) | MAPTCYP2D6CYP2C19EPHX1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, PRSS3, PRSS2 | MAPT 2629/4885CYP2D6 1605/4885CYP2C19 1191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.