Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12505826 | 0.81 | MPO (0.38) | MPODDB1CRBN | |
| SCHEMBL1559639 | 0.78 | MPO (0.40) | MPODDB1CRBN | |
| SCHEMBL1559643 | 0.78 | MPO (0.40) | MPODDB1CRBN | |
| SCHEMBL16437216 | 0.77 | OGA (0.39) | HCRTR1 | |
| SCHEMBL17085006 | 0.77 | KHK (0.40) | DDB1CRBN | |
| SCHEMBL23511661 | 0.76 | KHK (0.38) | HCRTR1 | |
| SCHEMBL25819003 | 0.75 | CRBN (0.44) | DDB1CRBN | |
| SCHEMBL12413741 | 0.74 | JAK2 (0.40) | — | |
| SCHEMBL1558733 | 0.74 | MPO (0.37) | MPODDB1CRBN | |
| SCHEMBL10203227 | 0.74 | ACHE (0.47) | HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569298-B2 | Pyridine compounds | ASTRAZENECA AB (SE) | 2013-10-29 | — | — | US | disclosed |
| US-8569298-B2 | Pyridine compounds | ASTRAZENECA AB (SE) | 2013-10-29 | — | — | US | disclosed |
| US-20110166139-A1 | PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166139-A1 | PYRIDINE COMPOUNDS | PTK2, PTK2B, PFKP | MPO 1357/4885DDB1 2412/4885CRBN 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.