SCHEMBL124161

SCHEMBL124161

Cc1cncc2cccc(S(=O)(=O)N3CCCNC[C@@H]3C)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 12/20 1.00
ROCK1 Q13464 11/20 1.00
PRKACA P17612 5/20 1.00
PRKCD Q05655 5/20 1.00
PRKD3 O94806 4/20 1.00
PRKCZ Q05513 4/20 1.00
PRKACG P22612 4/20 1.00
PRKACB P22694 4/20 1.00
PKN2 Q16513 3/20 1.00
AURKB Q96GD4 3/20 1.00
PRKD2 Q9BZL6 3/20 1.00
PLK4 O00444 2/20 1.00
MARK3 P27448 2/20 1.00
PRKAA1 Q13131 2/20 1.00
MARK2 Q7KZI7 2/20 1.00
MAP4K4 O95819 2/20 1.00
CHEK2 O96017 2/20 1.00
AKT1 P31749 2/20 1.00
PRKX P51817 2/20 1.00
CDK5 Q00535 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29372951 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL6969527 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL226317 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL30069136 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL29378010 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL29677841 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL2456059 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL507871 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL2461354 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL29781011 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 471 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026090172-A1 CELL CULTURE SYSTEMS COMPRISING MICROPATTERNED ARRAYS AND METHODS OF USE ALTIS BIOSYSTEMS, INC. (US) 2026-04-30 WO claimed
EP-3843845-B1 INHIBITION OF PROTEIN KINASES TO TREAT FRIEDREICH ATAXIA UNIV MASSACHUSETTS (US) 2026-03-11 EP claimed
EP-4692329-A1 COMPOSITION FOR INDUCING DIRECT DIFFERENTIATION OF STEM CELLS INTO CORNEAL ENDOTHELIAL CELLS AND METHOD FOR INDUCING DIRECT DIFFERENTIATION USING SAME The Asan Foundation (KR) 2026-02-11 EP claimed
EP-4636079-A1 METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO CORNEAL ENDOTHELIAL CELLS AND USE THEREOF The Asan Foundation (KR) 2025-10-22 EP claimed
US-20250206779-A1 ANGIOTENSIN-(1-9) ANALOGUE BASED ON D AMINO ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF UNIVERSIDAD DE CHILE (CL) 2025-06-26 US claimed
WO-2024210619-A1 COMPOSITION FOR INDUCING DIRECT DIFFERENTIATION OF STEM CELLS INTO CORNEAL ENDOTHELIAL CELLS AND METHOD FOR INDUCING DIRECT DIFFERENTIATION USING SAME 재단법인 아산사회복지재단 2024-10-10 WO claimed
EP-4337675-A1 ANGIOTENSIN-(1-9) ANALOGUE BASED ON D AMINO ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Universidad De Chile (CL) 2024-03-20 EP claimed
EP-3372673-B1 METHOD FOR PRODUCING CEREBELLAR PROGENITOR TISSUE RIKEN (JP) 2023-12-13 EP claimed
WO-2022238734-A1 ANGIOTENSIN-(1-9) ANALOGUE BASED ON D AMINO ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF UNIVERSIDAD DE CHILE (CL) 2022-11-17 WO claimed
CN-106795487-B Method for proliferating pancreatic progenitor cells 武田药品工业株式会社 2021-11-19 CN claimed
EP-2839831-A1 Modulators of the unconventional secretory pathway for use in the treatment of Alexander disease Rheinische Friedrich-Wilhelms-Universität Bonn (DE) 2015-02-25 EP claimed
EP-2377544-B1 PHARMACEUTICAL COMPOSITION CONTAINING ANGIOTENSIN-(1-9) FOR CARDIOVASCULAR, PULMONARY AND/OR CEREBRAL TREATMENT PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) 2014-10-22 EP claimed
WO-2014053709-A1 A METHOD FOR CULTURING STEM CELLS GLYKOS FINLAND OY (FI) 2014-04-10 WO claimed
US-20130123345-A1 METHOD OF TREATING A VIRAL INFECTION DYSFUNCTION BY DISRUPTING AN ADENOSINE RECEPTOR PATHWAY THE OHIO STATE UNIVERSITY (US) 2013-05-16 US claimed
US-20120172301-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING ANGIOTENSIN-(1-9), DERIVATIVES THEREOF, OR A VECTOR EXPRESSING ACE2, USEFUL FOR TREATING CARDIOVASCULAR, PULMONARY, CEREBRAL, AND/OR RENAL REMODELING PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE (CL) 2012-07-05 US claimed
EP-2377544-A2 PHARMACEUTICAL COMPOSITION CONTAINING ANGIOTENSIN-(1-9) FOR CARDIOVASCULAR, PULMONARY AND/OR CEREBRAL TREATMENT Pontificia Universidad Católica De Chile (CL) 2011-10-19 EP claimed
US-20110130388-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR AXIAL MYOPIA OSAKA UNIVERSITY (JP) 2011-06-02 US claimed
EP-2319539-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR AXIAL MYOPIA Osaka University (JP) 2011-05-11 EP claimed
WO-2005120475-A2 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF BACTERIAL INFECTIONS AND SEPSIS Technische Universität Dresden (DE) 2005-12-22 WO claimed
EP-0885888-B1 ISOQUINOLINE DERIVATIVES AND DRUGS HIDAKA HIROYOSHI DR (JP) 2003-08-13 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110130388-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR AXIAL MYOPIA RHOA, ROCK1, ROCK2 ROCK2 3/4885ROCK1 2/4885PRKACA 770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.