Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 11/20 | 1.00 |
| ▸ | PRKACA | P17612 | 5/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 5/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 4/20 | 1.00 |
| ▸ | PRKCZ | Q05513 | 4/20 | 1.00 |
| ▸ | PRKACG | P22612 | 4/20 | 1.00 |
| ▸ | PRKACB | P22694 | 4/20 | 1.00 |
| ▸ | PKN2 | Q16513 | 3/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 3/20 | 1.00 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 1.00 |
| ▸ | PLK4 | O00444 | 2/20 | 1.00 |
| ▸ | MARK3 | P27448 | 2/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 1.00 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 2/20 | 1.00 |
| ▸ | CHEK2 | O96017 | 2/20 | 1.00 |
| ▸ | AKT1 | P31749 | 2/20 | 1.00 |
| ▸ | PRKX | P51817 | 2/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372951 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| SCHEMBL226317 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| SCHEMBL30069136 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| SCHEMBL29378010 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| SCHEMBL124161 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| SCHEMBL29677841 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| Hydrochloric Acid SCHEMBL2456059 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| Hydrochloric Acid SCHEMBL507871 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| Hydrochloric Acid SCHEMBL2461354 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1PRKACAPRKCDPRKD3 | |
| Hydrochloric Acid SCHEMBL29781011 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1PRKACAPRKCDPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885888-B1 | ISOQUINOLINE DERIVATIVES AND DRUGS | HIDAKA HIROYOSHI DR (JP) | 2003-08-13 | — | — | EP | claimed |
| US-20230201219-A1 | METHODS OF TREATING AGITATION AND OTHER DEMENTIA-ASSOCIATED BEHAVIORAL SYMPTOMS | WOOLSEY PHARMACEUTICALS, INC. | 2023-06-29 | — | — | US | disclosed |
| US-20230172944-A1 | ROCK INHIBITORS FOR USE IN TREATING OR PREVENTING PULMONARY EDEMA | ATRIVA THERAPEUTICS GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| EP-3293256-A1 | AUTOMATED METHOD AND APPARATUS FOR EMBRYONIC STEM CELL CULTURE | Cellular Dynamics International, Inc. (US) | 2018-03-14 | — | — | EP | disclosed |
| US-9150829-B2 | Culture of pluripotent and multipotent cells on microcarriers | AGENCY FOR SCIENCE, TECHNOLOY AND RESEARCH (SG) | 2015-10-06 | — | — | US | disclosed |
| EP-2401364-B1 | DIFFERENTIATION OF PLURIPOTENT CELLS | CELLULAR DYNAMICS INT INC (US) | 2015-04-22 | — | — | EP | disclosed |
| US-8933071-B2 | Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-8933071-B2 | Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-8815585-B2 | Automated method and apparatus for embryonic stem cell culture | CELLULAR DYNAMICS INTERNATIONAL, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-8815585-B2 | Automated method and apparatus for embryonic stem cell culture | CELLULAR DYNAMICS INTERNATIONAL, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| US-20120009645-A1 | CULTURE OF PLURIPOTENT AND MULTIPOTENT CELLS ON MICROCARRIERS | AGENCY FOR SCIENCE, TECHNOLOGY, AND RESEARCH (SG) | 2012-01-12 | — | — | US | disclosed |
| US-20100279403-A1 | DIFFERENTIATION OF PLURIPOTENT CELLS | CELLULAR DYNAMICS INTERNATIONAL, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| WO-2010099539-A1 | DIFFERENTIATION OF PLURIPOTENT CELLS | CELLULAR DYNAMICS INTERNATIONAL, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| US-20100120750-A1 | METHODS FOR INDUCING POLYPLOIDIZATION OF MEGAKARYOCYTES AND FOR TREATING BLOOD AND BONE MARROW DISEASES AND DISORDERS | NORTHWESTERN UNIVERSITY (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100120750-A1 | METHODS FOR INDUCING POLYPLOIDIZATION OF MEGAKARYOCYTES AND FOR TREATING BLOOD AND BONE MARROW DISEASES AND DISORDERS | NORTHWESTERN UNIVERSITY (US) | 2010-05-13 | — | — | US | disclosed |
| US-20090029462-A1 | AUTOMATED METHOD AND APPARATUS FOR EMBRYONIC STEM CELL CULTURE | CELLULAR DYNAMICS INTERNATIONAL, INC. | 2009-01-29 | — | — | US | disclosed |
| US-20090029462-A1 | AUTOMATED METHOD AND APPARATUS FOR EMBRYONIC STEM CELL CULTURE | CELLULAR DYNAMICS INTERNATIONAL, INC. | 2009-01-29 | — | — | US | disclosed |
| EP-0885888-B1 | ISOQUINOLINE DERIVATIVES AND DRUGS | HIDAKA HIROYOSHI DR (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6153608-A | Isoquinoline derivatives and drugs | NIPPON SHINYAKU CO., LTD. (JP) | 2000-11-28 | — | — | US | disclosed |
| EP-0885888-A1 | ISOQUINOLINE DERIVATIVES AND DRUGS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230201219-A1 | METHODS OF TREATING AGITATION AND OTHER DEMENTIA-ASSOCIATED BEHAVIORAL SYMPTOMS | ROCK1, ROCK2, CIT | ROCK2 2/4885ROCK1 1/4885PRKACA 936/4885 |
| US-20230172944-A1 | ROCK INHIBITORS FOR USE IN TREATING OR PREVENTING PULMONARY EDEMA | ROCK1, ROCK2, NHERF1 | ROCK2 2/4885ROCK1 1/4885PRKACA 405/4885 |
| US-20100120750-A1 | METHODS FOR INDUCING POLYPLOIDIZATION OF MEGAKARYOCYTES AND FOR TREATING BLOOD AND BONE MARROW DISEASES AND DISORDERS | MPL, THPO, MCL1 | ROCK2 785/4885ROCK1 1018/4885PRKACA 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.