SCHEMBL226317

SCHEMBL226317

Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 12/20 1.00
ROCK1 Q13464 11/20 1.00
PRKACA P17612 5/20 1.00
PRKCD Q05655 5/20 1.00
PRKD3 O94806 4/20 1.00
PRKCZ Q05513 4/20 1.00
PRKACG P22612 4/20 1.00
PRKACB P22694 4/20 1.00
PKN2 Q16513 3/20 1.00
AURKB Q96GD4 3/20 1.00
PRKD2 Q9BZL6 3/20 1.00
PLK4 O00444 2/20 1.00
MARK3 P27448 2/20 1.00
PRKAA1 Q13131 2/20 1.00
MARK2 Q7KZI7 2/20 1.00
MAP4K4 O95819 2/20 1.00
CHEK2 O96017 2/20 1.00
AKT1 P31749 2/20 1.00
PRKX P51817 2/20 1.00
CDK5 Q00535 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29372951 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL6969527 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL30069136 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL29378010 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL124161 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
SCHEMBL29677841 1.00 ROCK2 (1.00) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL2456059 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL507871 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL2461354 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3
Hydrochloric Acid SCHEMBL29781011 0.99 ROCK2 (0.98) ROCK2ROCK1PRKACAPRKCDPRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3372673-B1 METHOD FOR PRODUCING CEREBELLAR PROGENITOR TISSUE RIKEN (JP) 2023-12-13 EP claimed
US-10781420-B2 Method for producing cerebellar progenitor tissue RIKEN (JP) 2020-09-22 US claimed
US-9980972-B2 Rho kinase inhibitors for use in treating familial amyotrophic lateral sclerosis GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZIN (DE) 2018-05-29 US claimed
EP-2825175-B1 RHO KINASE INHIBITORS FOR USE IN TREATING AMYOTROPHIC LATERAL SCLEROSIS Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin (DE) 2017-07-26 EP claimed
WO-2009116840-A2 CHEMICAL REAGENTS REGULATING STEM CELL FATE INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) 2009-09-24 WO claimed
WO-2008022182-A1 METHODS FOR PROMOTING COUPLING BETWEEN BONE FORMATION AND RESORPTION THE UAB RESEARCH FOUNDATION (US) 2008-02-21 WO claimed
US-20260028584-A1 METHOD FOR EVALUATING AGGREGATION-SUPPRESSING ACTIVITY OR AGGREGATION-PROMOTING ACTIVITY ON AGGREGATING PROTEIN USING ORGANOID, AND METHOD FOR PRODUCING ORGANOID KANEKA CORPORATION (JP) 2026-01-29 US disclosed
US-12534705-B2 Method for producing pluripotent stem cells KANEKA CORPORATION (JP) 2026-01-27 US disclosed
EP-4338751-B1 COMBINATION OF SEPETAPROST AND NETARSUDIL FOR USE IN THE PROPHYLAXIS OR TREATMENT OF GLAUCOMA OR OCULAR HYPERTENSION SANTEN PHARMACEUTICAL CO LTD (JP) 2025-09-03 EP disclosed
US-20250250539-A1 METHOD FOR EVALUATING ACTIVITY OF INHIBITING OR PROMOTING AGGREGATION OF AGGREGATING PROTEINS KANEKA CORPORATION (JP) 2025-08-07 US disclosed
EP-4597103-A1 METHOD FOR ASSESSING COAGULATION INHIBITION ACTIVITY OR COAGULATION PROMOTION ACTIVITY AGAINST COAGULATIVE PROTEIN Kaneka Corporation (JP) 2025-08-06 EP disclosed
WO-2025058089-A1 AGENT FOR SUPPRESSING AMYLOID β AGGREGATION/DEPOSITION AND AGENT FOR SUPPRESSING/IMPROVING COGNITIVE DECLINE OF SUBJECT 株式会社カネカ 2025-03-20 WO disclosed
US-12201602-B2 Medicament comprising combination of sepetaprost and Rho-associated coiled-coil containing protein kinase inhibitor SANTEN PHARMACEUTICAL CO., LTD. (JP) 2025-01-21 US disclosed
WO-2008015001-A1 RHO/ROCK/P13/AKT KINASE INHIBITORS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PROTOZOAN PARASITES UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI (FR) 2008-02-07 WO disclosed
WO-2007030697-A2 MODULATION OF NEUROGENESIS BY HDAC INHIBITION BRAINCELLS, INC. (US) 2007-03-15 WO disclosed
US-20060052367-A1 Remedy for glaucoma comprising rho kinase inhibitor and beta-blocker SANTEN PHARMACEUTICAL CO., LTD. (JP) 2006-03-09 US disclosed
US-20050245509-A1 Remedy for glaucoma comprising rho kinase inhibitor and prostaglandins SANTEN PHARMACECUTICAL CO., LTD. (JP) 2005-11-03 US disclosed
EP-1568382-A1 REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND &bgr;-BLOCKER SANTEN PHARMACEUTICAL CO., LTD. (JP) 2005-08-31 EP disclosed
EP-1541151-A1 REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND PROSTAGLANDINS SANTEN PHARMACEUTICAL CO., LTD. (JP) 2005-06-15 EP disclosed
EP-1074545-A1 ISOQUINOLINESULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Hidaka, Hiroyoshi (JP) 2001-02-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12534705-B2 Method for producing pluripotent stem cells WNT3A, WNT1, CTNNBL1 ROCK2 2693/4885ROCK1 2491/4885PRKACA 2594/4885
US-20260028584-A1 METHOD FOR EVALUATING AGGREGATION-SUPPRESSING ACTIVITY OR AGGREGATION-PROMOTING ACTIVITY ON AGGREGATING PROTEIN USING ORGANOID, AND METHOD FOR PRODUCING ORGANOID TTR, IAPP, TPM4 ROCK2 3149/4885ROCK1 3637/4885PRKACA 1470/4885
US-12201602-B2 Medicament comprising combination of sepetaprost and Rho-associated coiled-coil containing protein kinase inhibitor CIT, ROCK1, ROCK2 ROCK2 3/4885ROCK1 2/4885PRKACA 57/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.