Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | PPARD | Q03181 | 9/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12418537 | 0.91 | HSD17B1 (0.78) | HSD17B1KDM4EALDH1A1STSLMNA | |
| SCHEMBL7124873 | 0.89 | HSD17B1 (0.64) | HSD17B1KDM4EALDH1A1CYP3A4STS | |
| SCHEMBL7124870 | 0.89 | HSD17B1 (0.64) | HSD17B1KDM4EALDH1A1CYP3A4STS | |
| SCHEMBL12379505 | 0.88 | USP2 (0.64) | HSD17B1KDM4EALDH1A1CYP3A4STS | |
| SCHEMBL12379508 | 0.85 | HSD17B1 (0.80) | HSD17B1CYP3A4STSLMNAMAPT | |
| SCHEMBL7079771 | 0.82 | HSD17B1 (0.65) | HSD17B1KDM4EALDH1A1CYP3A4STS | |
| SCHEMBL12379510 | 0.81 | HSD17B1 (0.76) | HSD17B1KDM4EALDH1A1CYP3A4STS | |
| SCHEMBL12593636 | 0.81 | PPARD (0.58) | PPARDPPARA | |
| SCHEMBL12418333 | 0.80 | HSD17B1 (0.63) | HSD17B1KDM4EALDH1A1CYP3A4STS | |
| SCHEMBL6691697 | 0.80 | HSD17B1 (0.74) | HSD17B1KDM4EALDH1A1CYP3A4STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003783-B2 | Steroid 17 beta -hydroxysteroid dehydrogenase inhibitors substituted with one or more oxime groups, especially aromatase inhibitors used in the treatment of endocrine-dependent tumors, especially breast cancer | STERIX LIMITED (GB) | 2011-08-23 | — | — | US | disclosed |