Sugi Predict

Sugi Predict / Compounds / SCHEMBL12419482

SCHEMBL12419482

SCHEMBL12419482

OB(O)c1ccccc1-c1nnc(-c2ccco2)o1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 14/20 0.55
▸ KDM4E B2RXH2 13/20 0.55
▸ NPC1 O15118 13/20 0.55
▸ HSD17B10 Q99714 12/20 0.55
▸ ALDH1A1 P00352 12/20 0.55
▸ HPGD P15428 12/20 0.55
▸ SMN1; SMN2 Q16637 9/20 0.48
▸ TSHR P16473 7/20 0.48
▸ MAPT P10636 6/20 0.48
▸ TP53 P04637 6/20 0.48
▸ CYP1A2 P05177 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ LCLAT1 Q6UWP7 2/20 0.46
▸ GAA P10253 2/20 0.45
▸ POLB P06746 1/20 0.45
▸ PKM P14618 1/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ CASP3 P42574 2/20 0.43
▸ SENP8 Q96LD8 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29097578 0.80 MEN1 (0.39) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL6449025 0.80 RAB9A (0.70) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL6451121 0.80 KDM4E (0.60) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL12419458 0.78 RAB9A (0.62) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL6449967 0.76 NPC1 (0.60) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL6452343 0.76 RAB9A (0.63) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL11609635 0.76 ALDH1A1 (0.59) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL12419452 0.75 KDM4E (0.48) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL12260522 0.74 KDM4E (0.66) RAB9AKDM4ENPC1HSD17B10ALDH1A1
SCHEMBL12419470 0.72 ALDH1A1 (0.45) RAB9AKDM4ENPC1HSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
WO-2009126691-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC (US) 2009-10-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 RAB9A 1820/4885KDM4E 1442/4885NPC1 472/4885
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 RAB9A 1820/4885KDM4E 1442/4885NPC1 472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.