Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.65 |
| ▸ | P2RY14 | Q15391 | 11/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23557657 | 0.85 | PTGS2 (0.66) | PTGS2P2RY14S1PR1OPRD1KCNH2 | |
| SCHEMBL18031616 | 0.83 | HSD17B1 (0.75) | PTGS2P2RY14OPRD1KCNH2SIGMAR1 | |
| SCHEMBL182551 | 0.83 | P2RY14 (0.78) | PTGS2P2RY14S1PR1OPRD1KCNH2 | |
| SCHEMBL1119554 | 0.83 | PTGS2 (0.66) | PTGS2CA12CA9CA1CA2 | |
| SCHEMBL28068164 | 0.82 | PTGS2 (0.62) | PTGS2CA12CA9HDAC7HDAC6 | |
| SCHEMBL1430371 | 0.82 | P2RY14 (0.73) | P2RY14OPRD1KCNH2SIGMAR1TMEM97 | |
| Bromide SCHEMBL6256547 | 0.81 | PTGS2 (0.64) | PTGS2CA12CA9CA1CA2 | |
| SCHEMBL26628312 | 0.80 | PTGS2 (0.67) | PTGS2CA12CA9CA1CA2 | |
| SCHEMBL18031113 | 0.80 | ABCG2 (0.54) | PTGS2P2RY14S1PR1OPRD1KCNH2 | |
| SCHEMBL30608312 | 0.79 | P2RY14 (0.89) | P2RY14OPRD1KCNH2TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104230828-A | Method for synthesizing 1,4-disubstituted triazole compounds by one-pot process | UNIV ZHEJIANG | 2014-12-24 | — | — | CN | disclosed |
| US-20130096165-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2013-04-18 | — | — | US | disclosed |
| US-8362050-B2 | Compounds and methods for modulating G protein-coupled receptors | IRM LLC (BM) | 2013-01-29 | — | — | US | disclosed |
| US-20110172278-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096165-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | GRK2, GRK3, GPR3 | PTGS2 481/4885P2RY14 391/4885S1PR1 512/4885 |
| US-20110172278-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | GRK2, GRK3, GPR3 | PTGS2 481/4885P2RY14 391/4885S1PR1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.