Sugi Predict

Sugi Predict / Compounds / SCHEMBL12422223

SCHEMBL12422223

SCHEMBL12422223

CCOC(=O)c1nccn1P

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 6/20 0.42
▸ ALDH1A1 P00352 6/20 0.42
▸ HPGD P15428 4/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ JMJD6 Q6NYC1 2/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ TSHR P16473 1/20 0.39
▸ RECQL P46063 1/20 0.38
▸ MAPT P10636 2/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ MAPK1 P28482 2/20 0.38
▸ TBXAS1 P24557 1/20 0.37
▸ RGS12 O14924 1/20 0.37
▸ BRD4 O60885 1/20 0.37
▸ CDC7 O00311 1/20 0.37
▸ DBF4 Q9UBU7 1/20 0.37
▸ NUDT1 P36639 1/20 0.37
▸ CA12 O43570 1/20 0.37
▸ CA1 P00915 1/20 0.37
▸ CA2 P00918 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1822302 0.81 ALDH1A1 (0.46) KDM4EALDH1A1HPGDHSD17B10JMJD6
SCHEMBL151256 0.79 ALDH1A1 (0.42) KDM4EALDH1A1HPGDHSD17B10JMJD6
SCHEMBL12706154 0.79 LPO (0.42) KDM4EALDH1A1HPGDHSD17B10JMJD6
SCHEMBL3809364 0.79 LPO (0.44) KDM4EALDH1A1HPGDHSD17B10JMJD6
Hydrochloric Acid SCHEMBL18229865 0.78 ALDH1A1 (0.41) KDM4EALDH1A1HPGDHSD17B10JMJD6
Hydrochloric Acid SCHEMBL22322020 0.78 ALDH1A1 (0.41) KDM4EALDH1A1HPGDHSD17B10JMJD6
SCHEMBL29441633 0.77 ALDH1A1 (0.41) KDM4EALDH1A1HPGDHSD17B10JMJD6
SCHEMBL12410979 0.77 KDM4E (0.43) KDM4EALDH1A1HPGDHSD17B10JMJD6
SCHEMBL30554028 0.77 JMJD6 (0.42) KDM4EALDH1A1HPGDHSD17B10JMJD6
SCHEMBL4675474 0.76 ALDH1A1 (0.40) KDM4EALDH1A1HPGDHSD17B10JMJD6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9452996-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2016-09-27 — — US disclosed
US-9403804-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2016-08-02 — — US disclosed
US-9394289-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2016-07-19 — — US disclosed
US-20160122334-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-05-05 — — US disclosed
EP-2021329-B1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-04-13 — — EP disclosed
US-9296726-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA NV (BE) 2016-03-29 — — US disclosed
US-9266866-B2 Inhibitors of C-FMS kinase JANSSEN PHARMACEUTICA NV (BE) 2016-02-23 — — US disclosed
US-20160046602-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-02-18 — — US disclosed
EP-2016074-B1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-01-13 — — EP disclosed
EP-2016070-B1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-01-13 — — EP disclosed
US-20130281475-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2013-10-24 — — US disclosed
US-8497376-B2 4-Cyano-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(2,6-dioxo-piperidin-4-yl)-phenyl]-amide; tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent JANSSEN PHARMACEUTICA N.V. (BE) 2013-07-30 — — US disclosed
US-8481564-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA, N.V. (BE) 2013-07-09 — — US disclosed
US-20110195960-A1 INHIBITORS OF C-FMS KINASE ILLIG CARL R 2011-08-11 — — US disclosed
WO-2007124318-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 — — WO disclosed
WO-2007124322-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 — — WO disclosed
WO-2007124321-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 — — WO disclosed
WO-2007124319-A1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 — — WO disclosed
WO-2007124316-A1 HETEROCYCLIC COMPOUNDS AS INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 — — WO disclosed
US-20070249685-A1 4-Cyano-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(2,6-dioxo-piperidin-4-yl)-phenyl]-amide; tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent JANSSEN PHARMACEUTICA, N.V. (BE) 2007-10-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160122334-A1 INHIBITORS OF C-FMS KINASE MUSK, FRK, FES KDM4E 1770/4885ALDH1A1 4702/4885HPGD 4432/4885
US-20130281475-A1 INHIBITORS OF C-FMS KINASE MUSK, FRK, FES KDM4E 1770/4885ALDH1A1 4702/4885HPGD 4432/4885
US-20070249685-A1 4-Cyano-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(2,6-dioxo-piperidin-4-yl)-phenyl]-amide; tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent MUSK, CHUK, CAMK4 KDM4E 1708/4885ALDH1A1 3802/4885HPGD 3447/4885
US-20110195960-A1 INHIBITORS OF C-FMS KINASE MUSK, FRK, FES KDM4E 1770/4885ALDH1A1 4702/4885HPGD 4432/4885
US-20160046602-A1 INHIBITORS OF C-FMS KINASE FES, MUSK, FRK KDM4E 1642/4885ALDH1A1 4832/4885HPGD 4580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.