SCHEMBL12424970

SCHEMBL12424970

O=C1NC(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)=C2C(=O)NC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C12

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RXRA P19793 3/20 0.38
RXRB P28702 3/20 0.38
RXRG P48443 2/20 0.38
CES2 O00748 1/20 0.38
TDP2 O95551 2/20 0.35
NOTUM Q6P988 2/20 0.34
DAO P14920 2/20 0.34
IKBKB O14920 1/20 0.34
DDB1 Q16531 1/20 0.34
CRBN Q96SW2 1/20 0.34
PARP1 P09874 1/20 0.34
SOD1 P00441 1/20 0.33
KIF11 P52732 1/20 0.33
XPO1 O14980 1/20 0.33
STK10 O94804 1/20 0.32
SLK Q9H2G2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424995 0.91 TDP2 (0.43) RXRARXRBRXRGTDP2NOTUM
SCHEMBL12424992 0.90 AKR1C3 (0.33) RXRARXRBRXRGCES2TDP2
SCHEMBL12424928 0.89 RXRA (0.41) RXRARXRBRXRGTDP2NOTUM
SCHEMBL12424976 0.88 NOTUM (0.44) RXRANOTUMSTK10SLK
SCHEMBL12424982 0.88 RXRA (0.38) RXRARXRBRXRGTDP2KIF11
SCHEMBL12425001 0.88 NOTUM (0.32) RXRARXRBRXRGCES2TDP2
SCHEMBL12424903 0.82 NOTUM (0.48) RXRANOTUMSTK10SLK
SCHEMBL12424740 0.80 TDP2 (0.45) CES2TDP2NOTUMKIF11
SCHEMBL12509876 0.78 NOTUM (0.41) NOTUMDAO
SCHEMBL12424985 0.77 NOTUM (0.41) RXRANOTUMSTK10SLK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed