SCHEMBL12425009

SCHEMBL12425009

COc1cccc(F)c1C1=C2C(=O)NC(c3cc(N(C)C)ccc3F)=C2C(=O)N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.41
WEE1 P30291 1/20 0.41
STK10 O94804 12/20 0.39
SLK Q9H2G2 12/20 0.39
LRRK2 Q5S007 1/20 0.38
GSK3B P49841 3/20 0.38
CLK2 P49760 1/20 0.38
GSK3A P49840 1/20 0.38
STK33 Q9BYT3 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
TLK1 Q9UKI8 1/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
GLA P06280 1/20 0.38
GAA P10253 1/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CDK2 P24941 1/20 0.35
JAK2 O60674 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424878 0.84 ALDH1A1 (0.44) LRRK2KDM4EALDH1A1GLAGAA
SCHEMBL12424881 0.83 STK10 (0.45) CHEK1WEE1STK10SLKGSK3B
SCHEMBL12425012 0.81 ALDH1A1 (0.37) KDM4EALDH1A1HPGDHSD17B10JAK2
SCHEMBL12425005 0.74 JAK3 (0.53) STK10SLKALDH1A1JAK2JAK1
SCHEMBL12425020 0.73 STK10 (0.44) CHEK1STK10SLKGSK3BCLK2
SCHEMBL12425023 0.69 CA9 (0.41) STK10SLK
SCHEMBL12424872 0.68 CA9 (0.40) LRRK2KDM4E
SCHEMBL12424879 0.68 STK10 (0.50) STK10SLKGSK3BCLK2GSK3A
SCHEMBL12424901 0.68 GRIA1 (0.49) CHEK1WEE1STK10SLKGSK3B
SCHEMBL9042282 0.67 GSK3B (0.56) CHEK1STK10SLKGSK3BCLK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed