SCHEMBL12425012

SCHEMBL12425012

CN(C)c1ccc(F)c(C2=C3C(=O)NC(c4c(F)cc(F)cc4F)=C3C(=O)N2)c1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
JAK2 O60674 1/20 0.36
JAK1 P23458 1/20 0.36
JAK3 P52333 1/20 0.36
PDGFRB P09619 1/20 0.36
PARP1 P09874 1/20 0.32
CYP3A4 P08684 1/20 0.32
HPGD P15428 1/20 0.32
HIF1A Q16665 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
TGM2 P21980 1/20 0.32
KDM4E B2RXH2 1/20 0.32
APP P05067 1/20 0.31
MAPT P10636 1/20 0.31
DHODH Q02127 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424878 0.90 ALDH1A1 (0.44) ALDH1A1JAK2JAK1JAK3PDGFRB
SCHEMBL12425009 0.81 CHEK1 (0.41) ALDH1A1JAK2JAK1JAK3HPGD
SCHEMBL12424896 0.78 TGM2 (0.42) TGM2
SCHEMBL12425005 0.78 JAK3 (0.53) ALDH1A1JAK2JAK1JAK3
SCHEMBL12424872 0.73 CA9 (0.40) PARP1TDP1TGM2KDM4EMAPT
SCHEMBL12424869 0.70 NISCH (0.41) ALDH1A1PARP1TDP1MAPT
SCHEMBL12424925 0.70 JAK3 (0.49) ALDH1A1JAK2JAK1JAK3PDGFRB
SCHEMBL12424972 0.69 TGM2 (0.46) CYP3A4HPGDHIF1AHSD17B10TDP1
SCHEMBL12424887 0.69 PPOX (0.50) PARP1TGM2MAPT
SCHEMBL12425007 0.68 NOTUM (0.37) ALDH1A1HPGDDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed