Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.51 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3333790 | 0.80 | CHRNB2 (0.58) | L3MBTL3MBTD1PARP1L3MBTL1CHRNB2 | |
| SCHEMBL12425600 | 0.78 | CHRNA4 (0.60) | L3MBTL3L3MBTL1GABRPGABRDGABRA1 | |
| SCHEMBL12426761 | 0.78 | CDK4 (0.51) | L3MBTL3MBTD1L3MBTL1PIK3CAMTOR | |
| SCHEMBL12425265 | 0.76 | GABRP (0.46) | L3MBTL3L3MBTL1CDK4GABRPGABRD | |
| SCHEMBL3334199 | 0.76 | PARP1 (0.47) | L3MBTL3MBTD1PARP1L3MBTL1CHRNB2 | |
| SCHEMBL3332699 | 0.74 | CHRNA4 (0.61) | L3MBTL3MBTD1PARP1L3MBTL1CHRNB2 | |
| SCHEMBL12425779 | 0.74 | KMT5A (0.43) | L3MBTL3L3MBTL1PIK3CAMTORGABRP | |
| SCHEMBL12425692 | 0.74 | HRH4 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4HRH4 | |
| SCHEMBL3332546 | 0.72 | CHRNB2 (0.63) | L3MBTL3MBTD1PARP1L3MBTL1CHRNB2 | |
| SCHEMBL12426765 | 0.72 | KMT5A (0.39) | L3MBTL3L3MBTL1PIK3CAMTORGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101409-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 | NOVARTIS AG (CH) | 2011-08-25 | — | — | WO | disclosed |