SCHEMBL12425600

SCHEMBL12425600

Nc1ccc(C(=O)N2CC3CNCC3C2)cn1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA4 P43681 16/20 0.60
CHRNB2 P17787 13/20 0.60
CHRNB4 P30926 13/20 0.60
CHRNA3 P32297 13/20 0.60
CHRNA7 P36544 13/20 0.60
L3MBTL3 Q96JM7 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
GABRP O00591 1/20 0.46
GABRD O14764 1/20 0.46
GABRA1 P14867 1/20 0.46
GABRB1 P18505 1/20 0.46
GABRG2 P18507 1/20 0.46
GABRB3 P28472 1/20 0.46
GABRA5 P31644 1/20 0.46
GABRA3 P34903 1/20 0.46
GABRA2 P47869 1/20 0.46
GABRB2 P47870 1/20 0.46
GABRA4 P48169 1/20 0.46
GABRE P78334 1/20 0.46
GABRA6 Q16445 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12426757 0.85 CHRNB2 (0.44) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL12425265 0.80 GABRP (0.46) CHRNA4CHRNB2CHRNA3L3MBTL3L3MBTL1
SCHEMBL12425404 0.78 L3MBTL3 (0.51) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL13403401 0.78 SIGMAR1 (0.54) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL12425358 0.78 CHRNB2 (0.64) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL21245555 0.77 NPC1 (0.60) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL12425361 0.77 GABRP (0.46) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL12425333 0.77 CDK4 (0.44) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL12858710 0.75 CHRNA4 (1.00) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL6173203 0.75 HPGD (0.59) L3MBTL3L3MBTL1GABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011101409-A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 NOVARTIS AG (CH) 2011-08-25 WO disclosed