Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.61 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.52 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.52 |
| ▸ | TET3 | O43151 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.51 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22804962 | 0.84 | KIF11 (0.61) | HDAC1KIF11HDAC2HDAC4HDAC8 | |
| SCHEMBL12408499 | 0.82 | KIF11 (0.55) | KIF11 | |
| SCHEMBL1071505 | 0.82 | KIF11 (0.55) | KIF11 | |
| SCHEMBL30440640 | 0.82 | KIF11 (0.55) | KIF11 | |
| SCHEMBL16806882 | 0.81 | HDAC1 (0.70) | HDAC1HDAC2HDAC4HDAC8HDAC6 | |
| SCHEMBL28217117 | 0.78 | KIF11 (0.66) | KIF11 | |
| SCHEMBL8069561 | 0.77 | KIF11 (0.64) | KIF11 | |
| SCHEMBL22203071 | 0.77 | KIF11 (0.55) | HDAC1KIF11 | |
| SCHEMBL16806734 | 0.76 | HDAC1 (0.70) | HDAC1HDAC2HDAC4HDAC8HDAC6 | |
| SCHEMBL32690705 | 0.76 | HDAC1 (0.48) | HDAC1HDAC2HDAC4HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260382-B2 | Methods of reducing virulence in bacteria | UWM RESEARCH FOUNDATION (US) | 2016-02-16 | — | — | US | disclosed |
| US-9260382-B2 | Methods of reducing virulence in bacteria | UWM RESEARCH FOUNDATION (US) | 2016-02-16 | — | — | US | disclosed |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | DUKE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | DUKE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| WO-2011103189-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | UWM RESEARCH FOUNDATION, INC. (US) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | PGLS, RRS1, MRPL21 | HDAC1 3651/4885KIF11 4111/4885HDAC2 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.