Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242700 | 1.00 | DAO (0.56) | DAOGPR35HPGDKDM4EALDH1A1 | |
| SCHEMBL1244885 | 0.83 | DAO (0.61) | DAOGPR35HPGDKDM4EALDH1A1 | |
| SCHEMBL1244142 | 0.81 | DAO (0.59) | DAOGPR35HPGDKDM4EALDH1A1 | |
| SCHEMBL1244698 | 0.81 | DAO (0.53) | DAOHPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL1244700 | 0.81 | DAO (0.53) | DAOHPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL12890085 | 0.81 | ALDH1A1 (0.40) | DAOHPGDKDM4EALDH1A1LMNA | |
| SCHEMBL1242714 | 0.76 | DAO (0.65) | DAOGPR35HPGDKDM4EALDH1A1 | |
| SCHEMBL1244073 | 0.73 | DAO (0.65) | DAOGPR35HPGDKDM4EALDH1A1 | |
| SCHEMBL1244762 | 0.72 | DAO (1.00) | DAOGPR35HPGDALDH1A1ALOX15 | |
| SCHEMBL1244217 | 0.72 | DAO (0.65) | DAOGPR35HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-20100029741-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2010-02-04 | — | — | US | disclosed |
| US-20100022612-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2010-01-28 | — | — | US | disclosed |
| US-7579370-B2 | Fused heterocycles | SEPRACOR INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004328-A1 | FUSED HETEROCYCLES | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022612-A1 | FUSED HETEROCYCLES | AHR, HAX1, HRH3 | DAO 2452/4885GPR35 833/4885HPGD 1789/4885 |
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | DAO, DDO, AOX1 | DAO 1/4885GPR35 3228/4885HPGD 1217/4885 |
| US-20100029741-A1 | FUSED HETEROCYCLES | CHRNA4, CHRNB4, CHRNA3 | DAO 1545/4885GPR35 496/4885HPGD 1302/4885 |
| US-20080004328-A1 | FUSED HETEROCYCLES | HRH3, HRH4, AHR | DAO 2936/4885GPR35 877/4885HPGD 2102/4885 |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | DAO, DDO, AOX1 | DAO 1/4885GPR35 3379/4885HPGD 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.