Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Piperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL5874248 | 1.00 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA | |
| Piperidine SCHEMBL5874242 | 1.00 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA | |
| Piperidine SCHEMBL9857707 | 1.00 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA | |
| Azepane SCHEMBL7914286 | 0.97 | ALDH1A1 (0.56) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA | |
| Pyrrolidine SCHEMBL23354581 | 0.97 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA | |
| Pyrrolidine SCHEMBL29601650 | 0.97 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA | |
| Pyrrolidine SCHEMBL28575035 | 0.97 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA | |
| Pyrrolidine SCHEMBL28409763 | 0.93 | ALDH1A1 (0.50) | ALDH1A1CXCR4SMN1; SMN2FDPSMAPT | |
| Phosphoric Acid SCHEMBL28853896 | 0.89 | — | — | |
| Piperidine SCHEMBL6064824 | 0.89 | ALDH1A1 (0.47) | ALDH1A1CXCR4SMN1; SMN2CA2CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056973-B2 | High flow polyphenylene ether formulations | GENERAL ELECTRIC (US) | 2006-06-06 | — | — | US | claimed |
| US-20030176543-A1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-18 | — | — | US | claimed |
| EP-0552355-B1 | FLAME-RETARDED, CONDUCTIVE POLYPHENYLENE ETHER-BASED COMPOSITIONS | GEN ELECTRIC (US) | 1997-12-29 | — | — | EP | claimed |
| US-5294654-A | Polymer blend with fibers and phosphonate fire retardant compounds | GENERAL ELECTRIC COMPANY (US) | 1994-03-15 | — | — | US | claimed |
| EP-0552355-A1 | FLAME-RETARDED, CONDUCTIVE POLYPHENYLENE ETHER-BASED COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 1993-07-28 | — | — | EP | claimed |
| WO-1993004119-A1 | FLAME-RETARDED, CONDUCTIVE POLYPHENYLENE ETHER-BASED COMPOSITIONS | GENERAL ELECTRIC COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| EP-1678255-B1 | COMPOSITION COMPRISING FUNCTIONALIZED POLY(ARYLENE ETHER) AND ETHYLENE-ALKYL (METH)ACRYLATE COPOLYMER, METHOD FOR THE PREPARATION THEREOF, AND ARTICLES PREPARED THEREFROM | SABIC INNOVATIVE PLASTICS IP (NL) | 2012-11-14 | — | — | EP | disclosed |
| US-7893141-B2 | Halogen-free flame retardant polyester | SABIC INNOVATIVE PLASTICS IP B.V. (US) | 2011-02-22 | — | — | US | disclosed |
| EP-1276814-B1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS WITH DENTRITIC POLYMERS | SABIC INNOVATIVE PLASTICS IP (NL) | 2009-04-01 | — | — | EP | disclosed |
| US-7230046-B2 | Flame-retardant polyphenylene ether compositions, and related articles | GENERAL ELECTRIC COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| CN-1314741-C | Additive for thermoplastic resins and flame retardant resin compositions | GEN ELECTRIC (US) | 2007-05-09 | — | — | CN | disclosed |
| US-7211639-B2 | Composition comprising functionalized poly(arylene ether) and ethylene-alkyl (meth)acrylate copolymer, method for the preparation thereof, and articles prepared therefrom | GENERAL ELECTRIC COMPANY (US) | 2007-05-01 | — | — | US | disclosed |
| EP-1424357-B1 | Additive for thermoplastic resins and flame retardant resin compositions | GEN ELECTRIC (US) | 2006-11-02 | — | — | EP | disclosed |
| US-20020151652-A1 | High flow polyphenylene ether formulations with dendritic polymers | CITIBANK, N.A., AS COLLATERAL AGENT | 2002-10-17 | — | — | US | disclosed |
| US-6414084-B1 | COMPOSITION COMPRISING POLYPHENYLENE ETHER RESIN AND DENDRITIC POLYMER HAVING STARBURST CONFIGURATION AND COMPRISING POLYESTER BRANCHING UNITS BOUND TO CORE | GENERAL ELECTRIC COMPANY | 2002-07-02 | — | — | US | disclosed |
| WO-2002018485-A1 | FLAME-RETARDED POLYPHENYLENE ETHER COMPOSITION AND METHOD OF MAKING SAME | GENERAL ELECTRIC COMPANY (US) | 2002-03-07 | — | — | WO | disclosed |
| WO-2001079351-A1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS | GENERAL ELECTRIC COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |
| WO-2001079352-A1 | HIGH FLOW POLYPHENYLENE ETHER FORMULATIONS WITH DENTRITIC POLYMERS | GENERAL ELECTRIC COMPANY (US) | 2001-10-25 | — | — | WO | disclosed |
| EP-0552355-B1 | FLAME-RETARDED, CONDUCTIVE POLYPHENYLENE ETHER-BASED COMPOSITIONS | GEN ELECTRIC (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5294654-A | Polymer blend with fibers and phosphonate fire retardant compounds | GENERAL ELECTRIC COMPANY (US) | 1994-03-15 | — | — | US | disclosed |