Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.33 |
| ▸ | PI4KA | P42356 | 2/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427509 | 0.98 | ALOX15 (0.47) | ALOX15HPGDCNR2TSHRSMN1; SMN2 | |
| SCHEMBL6004006 | 0.86 | ALOX15 (0.41) | ALOX15HPGDSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL7886968 | 0.81 | ALOX15 (0.44) | ALOX15SMN1; SMN2GAAPDE9AALDH1A1 | |
| SCHEMBL3061038 | 0.78 | ALOX15 (0.72) | ALOX15HPGDCNR2TSHRSMN1; SMN2 | |
| SCHEMBL10025048 | 0.77 | ALOX15 (0.41) | ALOX15HPGDCNR2TSHRSMN1; SMN2 | |
| SCHEMBL2076461 | 0.77 | PKM (0.57) | ALOX15HPGDALDH1A1PKMKDM4E | |
| SCHEMBL14824946 | 0.77 | ALDH1A1 (0.41) | ALOX15HPGDCNR2TSHRSMN1; SMN2 | |
| SCHEMBL10670539 | 0.75 | CNR2 (0.57) | CNR2SMN1; SMN2PDE9AALDH1A1MAPT | |
| SCHEMBL27737776 | 0.75 | HSD11B1 (0.40) | ALOX15HPGDCNR2KDM4EKMT2A | |
| SCHEMBL10674677 | 0.75 | CNR2 (0.44) | ALOX15CNR2SMN1; SMN2PDE9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351751-A1 | Substituted pyrazolopyrimidines | CEPHALON, INC. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |