Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | ACP3 | P15309 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL777378 | 0.76 | METAP1 (0.47) | METAP1ACP3ANPEPERAP2CA12 | |
| SCHEMBL18230965 | 0.70 | FDPS (0.55) | METAP1ACP3ANPEPERAP2CA12 | |
| SCHEMBL4104306 | 0.67 | METAP1 (0.49) | METAP1ACP3ANPEPERAP2CA12 | |
| SCHEMBL7435009 | 0.66 | METAP1 (0.51) | METAP1ACP3ANPEPERAP2METAP2 | |
| SCHEMBL7431441 | 0.66 | METAP1 (0.51) | METAP1ACP3ANPEPERAP2METAP2 | |
| SCHEMBL7436524 | 0.65 | METAP2 (0.44) | METAP1METAP2 | |
| SCHEMBL779405 | 0.65 | METAP1 (0.59) | METAP1ACP3ANPEPERAP2CA12 | |
| SCHEMBL13327340 | 0.64 | FDPS (0.52) | METAP1ACP3ANPEPERAP2CA12 | |
| SCHEMBL10533248 | 0.63 | CYP1A2 (0.38) | METAP1METAP2 | |
| SCHEMBL9170443 | 0.63 | METAP1 (0.44) | METAP1ACP3ANPEPERAP2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879878-B2 | such as {2-[({[7-(cyclohexylamino)-6-fluoro-4-oxo-1-[(3S)-tetrahydrofuran-3-yl]-1,4-dihydroquinolin-3-yl}carbonyl)amino]ethyl}phosphonic acid, used as platelet aggregation inhibitor and purinergic receptor (P2Y12) inhibitors; therapy for circulatory diseases involving thrombosis via platelet aggregation | ASTELLAS PHARMA INC. (JP) | 2011-02-01 | — | — | US | disclosed |