Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.51 |
| ▸ | ANPEP | P15144 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 6/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431441 | 1.00 | METAP1 (0.51) | METAP1ANPEPERAP2METAP2ACP3 | |
| SCHEMBL7431873 | 0.86 | METAP1 (0.45) | METAP1ANPEPERAP2METAP2REN | |
| SCHEMBL7423894 | 0.86 | METAP1 (0.45) | METAP1ANPEPERAP2METAP2REN | |
| SCHEMBL7431495 | 0.83 | METAP2 (0.44) | METAP1METAP2REN | |
| SCHEMBL7436524 | 0.83 | METAP2 (0.44) | METAP1METAP2REN | |
| SCHEMBL7438129 | 0.82 | METAP2 (0.43) | METAP1ANPEPERAP2METAP2REN | |
| SCHEMBL9575092 | 0.82 | METAP2 (0.43) | METAP1ANPEPERAP2METAP2REN | |
| SCHEMBL9574959 | 0.81 | METAP2 (0.48) | METAP1METAP2REN | |
| SCHEMBL18230965 | 0.76 | FDPS (0.55) | METAP1ANPEPERAP2ACP3 | |
| SCHEMBL7277378 | 0.74 | REN (0.47) | METAP1METAP2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217958-A | Hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| WO-1989007940-A1 | 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF | E.R. SQUIBB & SONS, INC. (US) | 1989-09-08 | — | — | WO | disclosed |
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | disclosed |