SCHEMBL12433757

SCHEMBL12433757

CCCCCc1ccc(-c2ccc(OC(F)(F)CCc3c(C)cc(OCC)c(F)c3C(F)(F)F)cc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
RARB P10826 8/20 0.35
RARA P10276 1/20 0.35
RARG P13631 1/20 0.35
RXRA P19793 2/20 0.34
RXRB P28702 2/20 0.34
RXRG P48443 2/20 0.34
CASP3 P42574 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
PPARA Q07869 2/20 0.33
PPARD Q03181 1/20 0.33
PPARG P37231 1/20 0.33
S1PR1 P21453 1/20 0.33
HSD11B1 P28845 1/20 0.32
SPHK2 Q9NRA0 1/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14035223 0.90 RXRA (0.36) MAPTRXRARXRBRXRGPPARA
SCHEMBL12433767 0.85 RXRA (0.36) RXRARXRBRXRGPPARAPPARD
SCHEMBL12433710 0.85 RXRA (0.33) RXRARXRBRXRGPPARAPPARD
SCHEMBL12433647 0.85 FAAH (0.39) RARBRARARARGS1PR1ALDH1A1
SCHEMBL12433620 0.82 CALM1 (0.32) LMNA
SCHEMBL12433638 0.81 MAPT (0.36) MAPTRAB9AL3MBTL1PPARAPPARD
SCHEMBL12433708 0.81 MAPT (0.40) MAPTRAB9AL3MBTL1RARBRARA
SCHEMBL12433840 0.81 RXRA (0.40) RXRARXRBRXRGPPARAPPARD
SCHEMBL12433731 0.80 RXRA (0.30) RXRARXRBRXRG
SCHEMBL12984795 0.79 ITGB3 (0.31) RXRARXRBRXRGPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7981486-B2 Compound having alkyl on benzene ring, liquid crystal composition having the compound, and liquid crystal display device having the liquid crystal composition JNC CORPORATION (JP) 2011-07-19 US disclosed
US-7846513-B2 Compound having alkyl on benzene ring, liquid crystal composition having the compound, and liquid crystal display device having the liquid crystal composition CHISSO CORPORATION (JP) 2010-12-07 US disclosed
US-20090230356-A1 COMPOUND HAVING ALKYL ON BENZENE RING, LIQUID CRYSTAL COMPOSITION HAVING THE COMPOUND, AND LIQUID CRYSTAL DISPLAY DEVICE HAVING THE LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 2009-09-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090230356-A1 COMPOUND HAVING ALKYL ON BENZENE RING, LIQUID CRYSTAL COMPOSITION HAVING THE COMPOUND, AND LIQUID CRYSTAL DISPLAY DEVICE HAVING THE LIQUID CRYSTAL COMPOSITION BRD1, CNOT1, CXCR1 MAPT 1175/4885RAB9A 3244/4885L3MBTL1 1313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.