Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14154752 | 0.91 | MTNR1A (0.48) | MTNR1AMTNR1BHTR1ASLC6A2ABCB11 | |
| SCHEMBL12435546 | 0.75 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4EALDH1A1HSD17B10 | |
| SCHEMBL152992 | 0.74 | MTNR1A (0.47) | MTNR1AMTNR1BDRD3KDM4EALDH1A1 | |
| SCHEMBL7993891 | 0.73 | MTNR1A (0.54) | MTNR1AMTNR1BKDM4ELMNAMAPT | |
| SCHEMBL6715526 | 0.71 | MTNR1A (0.60) | MTNR1AMTNR1BKDM4EHSD17B10LMNA | |
| SCHEMBL12388663 | 0.70 | CYP2D6 (0.59) | MTNR1AMTNR1BHTR1ASLC6A2ABCB11 | |
| SCHEMBL28586501 | 0.70 | MTNR1A (0.65) | MTNR1AMTNR1BKDM4EALDH1A1MAPT | |
| SCHEMBL11709903 | 0.69 | KDM4E (0.48) | MTNR1AMTNR1BKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4653784 | 0.68 | HTR1A (0.54) | MTNR1AMTNR1BHTR1ASLC6A2ABCB11 | |
| SCHEMBL8686875 | 0.68 | MTNR1A (0.56) | MTNR1AMTNR1BKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110189127-A1 | TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110189127-A1 | TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF | IDO1, IDO2, TPH1 | MTNR1A 89/4885MTNR1B 108/4885HTR1A 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.