Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.50 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | G6PD | P11413 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SHBG | P04278 | 2/20 | 0.45 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12436289 | 1.00 | CYP19A1 (0.50) | CYP19A1HSD17B3AKR1B10AKR1B1OR51E2 | |
| SCHEMBL12436318 | 0.94 | HSD17B3 (0.48) | CYP19A1HSD17B3AKR1B10AKR1B1OR51E2 | |
| SCHEMBL16330012 | 0.84 | CYP19A1 (0.51) | CYP19A1HSD17B3AKR1B10AKR1B1OR51E2 | |
| SCHEMBL12436211 | 0.78 | CYP19A1 (0.52) | CYP19A1HSD17B3AKR1B10AKR1B1OR51E2 | |
| SCHEMBL4263982 | 0.78 | CYP19A1 (0.60) | CYP19A1HSD17B3AKR1B10AKR1B1OR51E2 | |
| SCHEMBL12512966 | 0.77 | CYP19A1 (0.48) | CYP19A1HSD17B3AKR1B10AKR1B1OR51E2 | |
| SCHEMBL13656757 | 0.69 | HSD17B7 (0.60) | — | |
| SCHEMBL7529348 | 0.69 | HSD17B7 (0.60) | — | |
| SCHEMBL7527375 | 0.69 | HSD17B7 (0.60) | — | |
| SCHEMBL3798376 | 0.69 | CYP19A1 (0.51) | CYP19A1HSD17B3MAPK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178065-A1 | NOVEL CYP17 INHIBITORS | BIOMARIN PHARMACEUTICAL INC. (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178065-A1 | NOVEL CYP17 INHIBITORS | BIOMARIN PHARMACEUTICAL INC. (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178065-A1 | NOVEL CYP17 INHIBITORS | CYP17A1, CYP21A2, HSD17B1 | CYP19A1 5/4885HSD17B3 7/4885AKR1B10 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.