Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276112 | 0.82 | PTGDR2 (0.46) | NPSR1LMNAGAAKMT2AALDH1A1 | |
| SCHEMBL276088 | 0.82 | NPSR1 (0.45) | NPSR1LMNAGAAKMT2AALDH1A1 | |
| SCHEMBL12801867 | 0.73 | ALDH1A1 (0.55) | LMNAALDH1A1CYP1A2KDM4ETSHR | |
| SCHEMBL13765280 | 0.72 | LMNA (0.39) | NPSR1LMNAGAAKMT2AALDH1A1 | |
| SCHEMBL12437417 | 0.72 | L3MBTL1 (0.41) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL12323596 | 0.71 | ERN1 (0.47) | NPSR1LMNAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL12438307 | 0.71 | SMN1; SMN2 (0.33) | NPSR1LMNAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL12369334 | 0.69 | MAPT (0.41) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL12437210 | 0.68 | PPARA (0.38) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL13761094 | 0.68 | F10 (0.43) | NPSR1ALDH1A1SMN1; SMN2TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |