Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276597 | 0.84 | PTGDR2 (0.47) | PPARALTA4HEPHX2CDK1LMNA | |
| SCHEMBL12437417 | 0.72 | L3MBTL1 (0.41) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL13765280 | 0.72 | LMNA (0.39) | EPHX2LMNAGAAKMT2AALDH1A1 | |
| SCHEMBL12323596 | 0.72 | ERN1 (0.47) | LMNAKMT2AALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL28862098 | 0.71 | LTA4H (0.58) | PPARALTA4HEPHX2LMNAKMT2A | |
| SCHEMBL13878415 | 0.69 | CA2 (0.50) | PPARALTA4HEPHX2LMNACYP4A11 | |
| SCHEMBL12437404 | 0.68 | NPSR1 (0.45) | LMNAGAAKMT2AALDH1A1CYP1A2 | |
| Water SCHEMBL27754912 | 0.67 | CA2 (0.48) | PPARALTA4HEPHX2LMNACYP4A11 | |
| SCHEMBL13761093 | 0.67 | SLC7A5 (0.43) | GAAKMT2AALDH1A1 | |
| SCHEMBL17558153 | 0.66 | TUBB1 (0.46) | ALDH1A1TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |