Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16187963 | 0.83 | ALDH1A1 (0.36) | ALDH1A1CHRNB2CHRNA4KDM4ESMN1; SMN2 | |
| SCHEMBL17671197 | 0.81 | ALDH1A1 (0.35) | ALDH1A1CHRNB2CHRNA4KDM4ESMN1; SMN2 | |
| SCHEMBL20772360 | 0.81 | ALDH1A1 (0.35) | ALDH1A1CHRNB2CHRNA4KDM4ESMN1; SMN2 | |
| SCHEMBL12395925 | 0.81 | ALDH1A1 (0.35) | ALDH1A1CHRNB2CHRNA4KDM4ESMN1; SMN2 | |
| SCHEMBL16879136 | 0.80 | NNMT (0.34) | ALDH1A1KDM4ESMN1; SMN2GAALRRK2 | |
| SCHEMBL23845599 | 0.78 | CHRNB2 (0.36) | ALDH1A1CHRNB2CHRNA4KDM4ESMN1; SMN2 | |
| SCHEMBL1746425 | 0.77 | UHRF1 (0.48) | NNMT | |
| SCHEMBL15173500 | 0.77 | TDP1 (0.35) | ALDH1A1KDM4EGAAKAT2BBRD9 | |
| SCHEMBL31257580 | 0.77 | TDP1 (0.35) | ALDH1A1KDM4EGAAKAT2BBRD9 | |
| SCHEMBL1872686 | 0.77 | KAT2B (0.32) | KAT2BBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024105364-A1 | HETEROCYCLIC INHIBITORS OF CDC-LIKE KINASES | CURADEV PHARMA LTD (GB) | 2024-05-23 | — | — | WO | disclosed |
| EP-3730487-A1 | AZETIDINE DERIVATIVES AS FXR (NR1H4) MODULATORS | Gilead Sciences, Inc. (US) | 2020-10-28 | — | — | EP | disclosed |
| US-10011568-B2 | Cyclohexyl pyridine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2018-07-03 | — | — | US | disclosed |
| US-10011568-B2 | Cyclohexyl pyridine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2018-07-03 | — | — | US | disclosed |
| EP-3067349-B1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL (JP) | 2018-02-28 | — | — | EP | disclosed |
| US-20170298024-A1 | CYCLOHEXYL PYRIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-10-19 | — | — | US | disclosed |
| US-20170298024-A1 | CYCLOHEXYL PYRIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-10-19 | — | — | US | disclosed |
| US-9708266-B2 | Cyclohexyl pyridine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| US-9708266-B2 | Cyclohexyl pyridine derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| EP-3141541-A1 | CYCLOHEXYL-PYRIDINE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2017-03-15 | — | — | EP | disclosed |
| US-20170057920-A1 | CYCLOHEXYL PYRIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-03-02 | — | — | US | disclosed |
| US-20170057920-A1 | CYCLOHEXYL PYRIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-03-02 | — | — | US | disclosed |
| US-20160289206-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2016-10-06 | — | — | US | disclosed |
| US-20160289206-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2016-10-06 | — | — | US | disclosed |
| US-8426450-B1 | Substituted 4-phenyl pyridines having anti-emetic effect | HELSINN HEALTHCARE SA (CH) | 2013-04-23 | — | — | US | disclosed |
| US-8404708-B2 | Dual NK1/NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404708-B2 | Dual NK1/NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20110178055-A1 | DUAL NK1/NK3 RECEPTOR ANTAGONISTS | HOFFMANN TORSTEN | 2011-07-21 | — | — | US | disclosed |
| US-20110178055-A1 | DUAL NK1/NK3 RECEPTOR ANTAGONISTS | HOFFMANN TORSTEN | 2011-07-21 | — | — | US | disclosed |
| EP-1643998-B1 | DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA | HOFFMANN LA ROCHE (CH) | 2007-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178055-A1 | DUAL NK1/NK3 RECEPTOR ANTAGONISTS | TACR2, TAC3, TACR1 | ALDH1A1 1516/4885CHRNB2 801/4885CHRNA4 468/4885 |
| US-20170298024-A1 | CYCLOHEXYL PYRIDINE DERIVATIVE | CYP3A43, CYP3A5, CYP3A4 | ALDH1A1 600/4885CHRNB2 1316/4885CHRNA4 374/4885 |
| US-10011568-B2 | Cyclohexyl pyridine derivative | CYP3A43, CYP3A5, CYP3A4 | ALDH1A1 600/4885CHRNB2 1316/4885CHRNA4 374/4885 |
| US-20160289206-A1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | TACR1, CYP3A5, CNR1 | ALDH1A1 165/4885CHRNB2 2148/4885CHRNA4 704/4885 |
| US-20170057920-A1 | CYCLOHEXYL PYRIDINE DERIVATIVE | CYP3A43, CYP3A5, CYP3A4 | ALDH1A1 581/4885CHRNB2 1314/4885CHRNA4 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.