Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 7/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21297851 | 0.78 | L3MBTL1 (0.42) | L3MBTL1NPC1HSP90AA1KDM4EMAPT | |
| Ammonia Solution, Strong SCHEMBL28358675 | 0.77 | L3MBTL1 (0.41) | L3MBTL1NPC1HSP90AA1KDM4EMAPT | |
| SCHEMBL25966739 | 0.74 | KAT2B (0.35) | L3MBTL1NPC1HSP90AA1KDM4EMAPT | |
| SCHEMBL570108 | 0.72 | KDM4E (0.41) | L3MBTL1KDM4EMAPTMAOBKAT2B | |
| SCHEMBL31221234 | 0.72 | BRD4 (0.43) | L3MBTL1NPC1HSP90AA1KDM4EMAPT | |
| SCHEMBL626956 | 0.67 | L3MBTL1 (0.54) | L3MBTL1NPC1HSP90AA1KDM4EMAPT | |
| SCHEMBL1747623 | 0.67 | GSK3B (0.54) | L3MBTL1NPC1HSP90AA1MAPTHTT | |
| SCHEMBL20551427 | 0.65 | KDM5A (0.44) | L3MBTL1NPC1HSP90AA1KDM4EMAPT | |
| SCHEMBL22149167 | 0.65 | DYRK1A (0.49) | L3MBTL1NPC1HSP90AA1KDM4EFEN1 | |
| SCHEMBL31298603 | 0.65 | KDM5A (0.44) | L3MBTL1NPC1HSP90AA1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011095450-A1 | CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2011-08-11 | — | — | WO | disclosed |