Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 8/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21297851 | 0.98 | L3MBTL1 (0.42) | L3MBTL1NPC1HSP90AA1SLC6A2HTT | |
| SCHEMBL12439934 | 0.77 | L3MBTL1 (0.36) | L3MBTL1NPC1HSP90AA1SLC6A2HTT | |
| SCHEMBL25966739 | 0.74 | KAT2B (0.35) | L3MBTL1NPC1HSP90AA1SLC6A2HTT | |
| SCHEMBL31221234 | 0.72 | BRD4 (0.43) | L3MBTL1NPC1HSP90AA1HTTKDM4E | |
| SCHEMBL570108 | 0.72 | KDM4E (0.41) | L3MBTL1KDM4EMAPTMAOBFEN1 | |
| SCHEMBL23486245 | 0.71 | MAOB (0.31) | MAOB | |
| SCHEMBL14430215 | 0.71 | GRM4 (0.43) | L3MBTL1NPC1HSP90AA1SLC6A2HTT | |
| SCHEMBL23486198 | 0.71 | — | — | |
| Ammonia Solution, Strong SCHEMBL27710165 | 0.69 | SLC9A1 (0.42) | NPC1KDM4EMAPT | |
| SCHEMBL14620979 | 0.68 | ALDH1A1 (0.46) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110678468-B | 5, 6-fused bicyclic compounds and compositions thereof for the treatment of parasitic diseases | 诺华股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-110678468-A | 5, 6-fused bicyclic compounds and compositions thereof for the treatment of parasitic diseases | 诺华股份有限公司 | 2020-01-10 | — | — | CN | disclosed |