SCHEMBL12440841

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2327513	0.89	MET (0.42)	TGFBR1METFEN1CYP2C9
	SCHEMBL12440047	0.88	TGFBR1 (0.46)	TGFBR1MAP4K4METIDO1
	SCHEMBL12440044	0.88	FEN1 (0.43)	TGFBR1MAP4K4FEN1MAPK1PIM1
	SCHEMBL2325058	0.87	TGFBR1 (0.41)	TGFBR1MAP4K4METPAICSIDO1
	SCHEMBL13968474	0.86	KDR (0.36)	TGFBR1MAP4K4METPAICSACVR1
	SCHEMBL2320748	0.86	MET (0.40)	METHTR6FEN1ACVR1ACP1
	SCHEMBL2324653	0.86	FGFR3 (0.41)	TGFBR1METFEN1IDO1PIM1
	SCHEMBL2321729	0.84	MAPK1 (0.42)	MAP4K4FEN1MAPK1CYP11B2
	SCHEMBL12439724	0.84	PAICS (0.37)	TGFBR1METPAICSACVR1MAPK1
	SCHEMBL12439726	0.83	TGFBR1 (0.41)	TGFBR1MAP4K4METIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.