Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445770 | 0.89 | BACE1 (0.51) | BACE1 | |
| SCHEMBL12445476 | 0.89 | BACE1 (0.61) | BACE1 | |
| SCHEMBL12446184 | 0.89 | BACE1 (0.53) | BACE1HDAC1HDAC6PARP1 | |
| SCHEMBL12446154 | 0.84 | BACE1 (0.54) | BACE1HDAC1HDAC6PARP1 | |
| SCHEMBL12446234 | 0.83 | BACE1 (0.47) | BACE1 | |
| SCHEMBL12445479 | 0.80 | BACE1 (0.58) | BACE1PARP1 | |
| SCHEMBL7942075 | 0.78 | ALDH1A1 (0.51) | BACE1HDAC1HDAC6PARP1 | |
| SCHEMBL7941514 | 0.77 | BACE1 (0.82) | BACE1HDAC1HDAC6 | |
| SCHEMBL7943333 | 0.77 | HDAC1 (0.48) | BACE1HDAC1HDAC6 | |
| SCHEMBL12445826 | 0.75 | SMN1; SMN2 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |