Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.53 |
| ▸ | RHOA | P61586 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CBLB | Q13191 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942075 | 0.81 | ALDH1A1 (0.51) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL7943333 | 0.80 | HDAC1 (0.48) | SMN1; SMN2MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL12446162 | 0.79 | ALOX15 (0.47) | RAB9AMAPTALDH1A1GAAACKR3 | |
| SCHEMBL12446184 | 0.77 | BACE1 (0.53) | — | |
| SCHEMBL12445770 | 0.77 | BACE1 (0.51) | — | |
| SCHEMBL12445476 | 0.77 | BACE1 (0.61) | — | |
| SCHEMBL12446169 | 0.76 | BACE1 (0.47) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL12446154 | 0.76 | BACE1 (0.54) | ALDH1A1 | |
| SCHEMBL12445462 | 0.75 | BACE1 (0.55) | — | |
| SCHEMBL12445472 | 0.74 | BACE1 (0.41) | RAB9AMAPTALDH1A1GAAACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |