Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 7/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942075 | 0.87 | ALDH1A1 (0.51) | HDAC1HDAC6BACE1ALDH1A1MEN1 | |
| SCHEMBL7941942 | 0.82 | SORT1 (0.41) | BACE1APPTSHR | |
| SCHEMBL12446162 | 0.81 | ALOX15 (0.47) | HDAC1HDAC6ALDH1A1LMNAMAPT | |
| SCHEMBL7942651 | 0.80 | BACE1 (0.47) | BACE1APPSMN1; SMN2 | |
| SCHEMBL12445826 | 0.80 | SMN1; SMN2 (0.58) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL12445476 | 0.79 | BACE1 (0.61) | BACE1 | |
| SCHEMBL12446184 | 0.79 | BACE1 (0.53) | HDAC1HDAC6BACE1 | |
| SCHEMBL12445770 | 0.79 | BACE1 (0.51) | BACE1 | |
| SCHEMBL12446169 | 0.78 | BACE1 (0.47) | HDAC1HDAC6BACE1ALDH1A1MEN1 | |
| SCHEMBL12446154 | 0.77 | BACE1 (0.54) | HDAC1HDAC6BACE1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |