Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 6/20 | 0.36 |
| ▸ | CISD2 | Q8N5K1 | 4/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.31 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.31 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445797 | 0.85 | F10 (0.34) | PTGDR2F10CISD2CXCR2ICAM1 | |
| SCHEMBL7940504 | 0.73 | PTGDR2 (0.40) | PTGDR2F10CISD2CXCR2AURKA | |
| SCHEMBL12446317 | 0.73 | BACE1 (0.41) | AURKAAURKBNPC1RAB9A | |
| SCHEMBL12445900 | 0.67 | BACE1 (0.42) | — | |
| SCHEMBL7943357 | 0.62 | BACE1 (0.52) | — | |
| SCHEMBL7942773 | 0.60 | BACE1 (0.41) | F10CISD2 | |
| SCHEMBL7945236 | 0.60 | BACE1 (0.54) | SENP5SENP2SENP1MAPT | |
| SCHEMBL9757077 | 0.59 | GPR35 (0.65) | ICAM1SELE | |
| SCHEMBL9756981 | 0.58 | MAPK1 (0.53) | CISD2ICAM1SELELMNAMAPT | |
| SCHEMBL20838905 | 0.58 | ADORA1 (0.67) | CISD2NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |