Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | SENP5 | Q96HI0 | 6/20 | 0.32 |
| ▸ | SENP2 | Q9HC62 | 6/20 | 0.32 |
| ▸ | SENP1 | Q9P0U3 | 6/20 | 0.32 |
| ▸ | CISD2 | Q8N5K1 | 2/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445904 | 0.85 | PTGDR2 (0.38) | F10ICAM1SELEPTGDR2SENP5 | |
| SCHEMBL7942773 | 0.76 | BACE1 (0.41) | F10PRKCICISD2 | |
| SCHEMBL7945236 | 0.66 | BACE1 (0.54) | SENP5SENP2SENP1 | |
| SCHEMBL7940504 | 0.64 | PTGDR2 (0.40) | F10PTGDR2CISD2CXCR2 | |
| SCHEMBL7933199 | 0.63 | BACE1 (0.44) | — | |
| SCHEMBL9757077 | 0.59 | GPR35 (0.65) | ICAM1SELE | |
| SCHEMBL9756981 | 0.59 | MAPK1 (0.53) | ICAM1SELECISD2SMN1; SMN2 | |
| SCHEMBL24343769 | 0.58 | GPR35 (0.38) | ICAM1SELE | |
| SCHEMBL7943409 | 0.58 | RAB9A (0.45) | PRKCINPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14691616 | 0.57 | CA12 (0.53) | ICAM1SELENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |