Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.48 |
| ▸ | SELE | P16581 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10949281 | 0.88 | MAPK1 (0.45) | MAPK1LMNAICAM1SELEHPGD | |
| SCHEMBL17149269 | 0.86 | LMNA (0.50) | MAPK1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL14691616 | 0.85 | CA12 (0.53) | LMNAICAM1SELEHPGDALDH1A1 | |
| SCHEMBL15910659 | 0.84 | L3MBTL1 (0.58) | MAPK1LMNAICAM1SELEHPGD | |
| SCHEMBL10958206 | 0.83 | PFKFB3 (0.54) | MAPK1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL10954508 | 0.82 | MAPK1 (0.44) | MAPK1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL9757077 | 0.82 | GPR35 (0.65) | ICAM1SELEALDH1A1CA12CA1 | |
| SCHEMBL719061 | 0.80 | CISD2 (0.47) | MAPK1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL10953990 | 0.80 | MAPK1 (0.44) | MAPK1LMNAHPGDALDH1A1MAPT | |
| SCHEMBL30656333 | 0.79 | L3MBTL1 (0.49) | MAPK1LMNAICAM1SELEHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |