Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.34 |
| ▸ | TUBB | P07437 | 4/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244015 | 0.75 | KDM4E (0.38) | KDM4EALDH1A1GAAHSD17B10NPSR1 | |
| SCHEMBL30990197 | 0.70 | ALOX15 (0.44) | KDM4EALDH1A1GAANPSR1MAPT | |
| SCHEMBL27385781 | 0.69 | GABRA1 (0.44) | KDM4EALDH1A1GAAHSD17B10NPSR1 | |
| SCHEMBL1242463 | 0.69 | KDM4E (0.38) | KDM4EALDH1A1GAAHSD17B10NPSR1 | |
| SCHEMBL3338049 | 0.68 | MEN1 (0.58) | KDM4EALDH1A1GAAHSD17B10NPSR1 | |
| SCHEMBL12388669 | 0.67 | KDM4E (0.34) | KDM4EALDH1A1GAAHSD17B10NPSR1 | |
| SCHEMBL2735787 | 0.67 | KMT2A (0.55) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL19500074 | 0.66 | KDM4C (0.37) | KDM4EALDH1A1GAAHSD17B10NPSR1 | |
| SCHEMBL829225 | 0.66 | MEN1 (0.45) | KDM4EALDH1A1GAAHSD17B10NPSR1 | |
| SCHEMBL6400977 | 0.66 | KDM4E (0.41) | KDM4EALDH1A1GAAHSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-7884124-B2 | such as 2-Fluoro-4H-furo[3,2-b]pyrrole-5-carboxylate acid, used for the treatment of neuropathic pain, Alzheimer's disease, schizophrenia, ataxia and convulsions | SEPRACOR INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | DAO, DDO, AOX1 | KDM4E 2046/4885ALDH1A1 622/4885GAA 830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.