Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.55 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 5/20 | 0.50 |
| ▸ | BCR | P11274 | 5/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.50 |
| ▸ | PRKCA | P17252 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | PRKACG | P22612 | 1/20 | 0.48 |
| ▸ | PRKACB | P22694 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667082 | 0.85 | SYK (0.60) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL6508664 | 0.83 | CAMK2D (0.69) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL1667452 | 0.83 | SYK (0.58) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL12275241 | 0.81 | PLK1 (0.61) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL1667404 | 0.81 | IKBKB (0.62) | SYKSMG1CDK2IKBKBCHUK | |
| SCHEMBL12276265 | 0.80 | PIK3CG (0.69) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL12522374 | 0.80 | JAK2 (0.60) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL12274368 | 0.80 | SYK (0.58) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL12274499 | 0.79 | PLK1 (0.73) | SYKSMG1CDK4CDK2BRD4 | |
| SCHEMBL1667086 | 0.79 | PLK1 (0.68) | SYKSMG1CDK4CDK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | TBK1, NFKBIA, IKBKB | SYK 112/4885SMG1 305/4885CDK4 645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.